Donald L. Lamm, MD, FACS

Donald L. Lamm, MD, FACS

BCG Oncology

Phoenix, Arizona

After 28 years in academic practice Dr. Donald Lamm, MD, FACS, launched his private practice in Fall 2004. Dr. Lamm graduated AOA from UCLA and did a rotating internship at the University of Oregon HSC in Portland. He did family practice for two years as Director of the Colville Indian Health Service Clinic before returning to UCLA for a year of General Surgery and UCSD for urology residency. During his urology residency he developed an animal model for bladder cancer and found that Bacillus Calmette Guerin (the TB vaccine, BCG) inhibited tumor growth. After residency he and his family moved to San Antonio where Don began his academic career as Assistant Professor of Surgery at the University of Texas Health Sciences Center. During his 9 years in Texas he rose in rank to Professor and Acting Chairman of the Division of Urology. His VA and NIH research resulted in clinical studies that led to the FDA approval of BCG for bladder cancer. Subsequent work by Dr. Lamm, then Chairman of the Department of Urology at West Virginia University, demonstrated that BCG immunotherapy is superior to Adriamycin and Mitomycin C chemotherapy for superficial bladder cancer, significantly reducing the risk of bladder cancer progression to muscle invasion and metastasis. Dr. Lamm's work is in part responsible for bladder cancer being one of only 5 cancers in the United States that has seen a reduced mortality despite an increased incidence. This reduction in mortality coincides with a reduction in the number of patients who lose their bladder as a result of radical cystoprostatectomy for muscle invasive or aggressive superficial disease. Three years ago Don was recruited to the Mayo Clinic, Scottsdale as Vice Chair for Research in the Department of Urology. Having practiced and taught general urology for 3 decades, he has now decided to limit his practice exclusively to his primary interest, urologic oncology. New to private practice, he greatly appreciates the good advice, help and welcome he has received from the private community. He is excited about the potential of expanding research in the private sector and hopes to establish a cooperative research consortium in Arizona to advance the care of patients with genitourinary cancers.

Articles by Donald L. Lamm, MD, FACS

BCG Failure: Defining Failure and Managing Difficult Cases of Non-Muscle Invasive Bladder Cancer

Donald L. Lamm, MD, FACS, Director of BCG Oncology and Clinical Professor of Surgery at the University of Arizona College of Medicine, discusses the criteria required of studies looking for alternative drug therapies to Bacillus Calmette-Guerin (BCG) to treat non-muscle invasive bladder cancer (NMIBC). Because there are many BCG refractory, recurrent, intolerant, and unresponsive patients, and because there is a global shortage of BCG, new drugs are much needed. To get funding, studies will require FDA approval, and Dr. Lamm suggests that researchers are more likely to receive approval quickly by using standard definitions and providing clear follow-up and end-points in their proposals.

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