Management of Disease Recurrence in Localized Prostate Cancer
Laurence Klotz, MD, FRCSC, discusses the complexities surrounding salvage therapy and focal therapy. Dr. Klotz explores the challenges that arise when managing local failure after radiation, providing insights into the polarized perspectives on the significance of focal therapy. He highlights the striking similarities in disease control achieved through various modalities of salvage therapy, shedding light on the potential benefits of radiation in mitigating genitourinary (GU) and gastrointestinal (GI) toxicity.
Dr. Klotz emphasizes the need to redefine treatment goals in focal therapy, urging a shift towards preventing metastasis and mortality as primary objectives, rather than seeking complete cancer eradication. Furthermore, the presentation discusses the captivating concept of “invisible tumors” and their favorable genetic features, aligning with the emerging principles of image-based management and its integration with focal therapy, allowing for personalized, targeted treatments that hold promise for improved patient outcomes.
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