Latest Videos

Evaluation and Management of Localized and Recurrent Prostate Cancer: Genetic Cancer Profiling

Alan Pollack, MD, PhD, Professor and Chair in the Department of Radiation Oncology at University of Miami Health, looks at genetic cancer profiling for prostate cancer risk assessment and its implications for treatment. He begins with a discussion of the development of a habitat risk scoring system for prostate cancer which, via quantitative pixel by pixel assessment, can generate high-risk volumes for targeting. Dr. Pollack then moves on to transcriptome analysis using genomic classifiers like Decipher, noting that these classifiers have a relationship with Gleason score, though it is not absolute, and can predict 10-year distant metastasis. He also considers how to understand genomic risk of habitats from quantitative MRI, observing the significant connections between radiogenomic features and transcriptomic features. Dr. Pollack concludes with a discussion of how genomic signatures might influence critical management, going through how Decipher scores could change risk stratification and highlighting several trials looking at habitat targeted radiotherapy.

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Sphincter-Saving Technique in HoLEP Surgery

As part of Grand Rounds in Urology’s ongoing series highlighting urologists working in Asia, Seung-June Oh, MD, PhD, Professor of Urology at Seoul National University in Seoul, South Korea, explains and demonstrates his sphincter-saving technique for holmium laser enucleation of the prostate (HoLEP) surgery. After an introduction by Peter K.F. Chiu, MD, PhD, FRCSEd, Dr. Oh goes over the benefits and difficulties of HoLEP for benign prostatic hyperplasia, emphasizing the problems of post-operative urinary incontinence. He then goes over strategies for maximally preserving the continence mechanism during HoLEP and introduces his Early Inverted V-shaped Apical Mucosal (EVAMI) Technique before showing footage of a routine HoLEP surgery. The presentation concludes with a question and answer session led by Dr. Chiu.

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Urine Biomarkers for the Detection of Urothelial Carcinoma

Siamak Daneshmand, MD, Associate Professor of Urology and Director of Clinical Research at the University of Southern California discusses the ability of urinary markers to rule out bladder cancer and decrease the frequency of and need for cystoscopy and cytology. He goes over the limitations and adverse effects of cystoscopy and cytology before summarizing the findings of several studies looking at different urinary biomarkers for bladder cancer, including Cxbladder, Bladder EpiCheck, Bladder CARE™, and Decipher Bladder.

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