Nazema Y. Siddiqui, MD, MHSc, presented “Overactive Bladder / Urge Urinary Incontinence & the Urinary Microbiome” for the Grand Rounds in Urology audience in July 2020.

How to cite: Siddiqui, Nazema Y. Overactive Bladder / Urge Urinary Incontinence & the Urinary Microbiome” July 2020. Accessed Jul 2024.

Overactive Bladder (OAB) / Urge Urinary Incontinence (UUI) & the Urinary Microbiome – Summary:

Nazema Y. Siddiqui, MD, MHSc, Associate Professor of Obstetrics & Gynecology at Duke University, discusses studies that investigate the urinary microbiome and its links to overactive bladder and urge urinary incontinence. She specifically identifies BMI, age, and estrogen levels as leading potential variables for predicting a patient’s urinary microbiome, and posits that longitudinal studies and computational models to better understand the microbiome will be necessary to make this knowledge useful for treatment and diagnosis of OAB and UUI in the future.

For more information on recurrent UTI and the urinary microbiome, visit our Next Generation Learning Center.


Dr. Siddiqui completed fellowship training in Female Pelvic Medicine & Reconstructive Surgery in 2010. She has remained on faculty at Duke University where she clinically treats women with a range of pelvic floor disorders, and has received NIH funding towards clinical and translational research. Her research focuses on urologic disorders that are common in aging women, such as urgency urinary incontinence (leakage associated with overactive bladder), and recurrent urinary tract infections. For both of these issues, the urinary microbiome has been implicated as a potential causative or exacerbating factor. Therefore, her research group has recently become focused on characterizing age-related changes in the urinary microbiome, and further defining how these alterations relate to urinary disorders in women.