Topic: Advanced Disease

Bladder Cancer and Immunotherapy

Jennifer M. Taylor, MD, MPH, provides a brief overview of the basic scientific concepts of cancer cell suppression with checkpoint inhibitors. She also reviews the initial clinical trials for atezolizumab and pembrolizumab, larger trials for various immunotherapies for bladder cancer, toxicity reports, and ongoing research regarding these drugs in different combinations and disease states.

Read More

Updates on Immunotherapy for Bladder Cancer

Daniel P. Petrylak, MD, discusses new treatments for metastatic bladder cancer and the importance of accurate PD-L1 markers. He also offers his predictions for bladder cancer checkpoint inhibitor therapy and second-line agents for patients who do not respond to checkpoint inhibitors.

Read More

New Targets for Advanced Bladder Cancer

Daniel P. Petrylak, MD, discusses the efficacy of checkpoint inhibitors in previously cisplatin treated metastatic urothelial carcinoma patients and the need for better biomarkers for checkpoint proteins. He also identifies future directions for treating the disease, including ipilimumab/nivolumab and epacadostat/ pembrolizumab combinations, and PD-L1 immunohistochemical staining.

Read More

Should Variant Histology Change Management of Bladder Cancer?

Peter Black, MD, FRCSC, fills in for Ashish Kamat, MD, at the 2nd annual IBCU, discussing why and how clinicians should adapt bladder cancer treatment based on variant histologies. Dr. Black identifies sub-types of bladder cancer and the way gene expression and squamous differentiation play a role in risk-stratifying the disease. He explains the proper management of each sub-type, including MD Anderson treatment algorithms for NMIBC and MIBC.

Read More

Neoadjuvant/ Adjuvant Chemotherapy—Are We Ready to Accept Neoadjuvant as the Gold Standard?

Seth P. Lerner, MD, argues for adopting neoadjuvant chemotherapy as the standard of care for metastatic bladder cancer patients. Dr. Lerner believes the urological community needs to define a better range of risk-stratification and more accurate diagnostic methods in order to do this. He discusses current developments in prognostic biomarkers and expression subtypes that he believes will make these necessary improvements possible.

Read More

Basic Concepts in Bladder Cancer Immunotherapy

Leonard G. Gomella, MD, FACS, reviews the basic scientific concepts of immunotherapy for bladder cancer, from why BCG is the “gold standard” of treatment and describing the mechanics of augmenting the immune system to eliminate tumor cells, to categorizing therapies into vaccine based, cytokines, monoclonal antibodies, checkpoint inhibitors, and CAR-T cells. He also explains why, generally, immunotherapy is particularly effective in the bladder cancer setting, as opposed to other cancers.

Read More
Loading

Join the GRU Community

- Why Join? -