Updates on Global Screening Trials: Where Are We Headed Next?

R. Jonathan Henderson, MD

R. Jonathan Henderson, MD, presented “Updates on Global Screening Trials: Where Are We Headed Next?” during the 35th International Prostate Cancer Update conference on February 9, 2025, in Vail, Colorado.

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How to cite: Henderson, R. Jonathan. “Updates on Global Screening Trials: Where Are We Headed Next?” February 9, 2025. Accessed Jan 2026. https://grandroundsinurology.com/updates-on-global-screening-trials-where-are-we-headed-next/

Updates on Global Screening Trials: Where Are We Headed Next? – Summary#

R. Jonathan Henderson, MD, Arkansas Urology, Little Rock, Arkansas, examines the evolution of prostate cancer screening. In this 15-minute presentation, Dr. Henderson emphasizes key trials and ongoing global efforts to improve detection.

The 2012 US Preventive Services Task Force recommendation against routine prostate cancer screening led to a rise in advanced cases, prompting a search for improved strategies. Dr. Henderson shares ongoing European initiatives, such as the PRAISE and PROBASE studies, which are exploring risk-based pathways incorporating PSA thresholds, MRI, and targeted biopsies. Dr. Henderson notably reviews the innovative Finnish PROSCREEN trial, which effectively integrates 4K scores and MRI to enhance the detection of clinically significant cancers while minimizing overdiagnosis.

US trials focus on tailored strategies for underserved populations, MRI-based screening, and noninvasive biomarkers. Dr. Henderson underscores the need for improved screening algorithms that balance precision, cost-effectiveness, and patient outcomes.

About the 35th International Prostate Cancer Update:
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The International Prostate Cancer Update (IPCU), is a multi-day, CME-accredited conference focused on new developments in prostate cancer treatment, diagnosis, and prevention. IPCU 35 will feature lectures, interactive discussions, panel roundtables, debates, and case reports. This conference is led by expert physicians and is designed for urologists, medical oncologists, radiation oncologists, and other healthcare professionals involved in the diagnosis and treatment of prostate cancer.

The goal of this educational program is to equip healthcare professionals involved in the diagnosis and treatment of prostate cancer with the up-to-date clinical knowledge and tools they need to best treat their patients. The program will discuss the treatment of prostate cancer from diagnosis to treating advanced and metastatic disease. The conference aims to give physicians exposure to a comprehensive review of treating prostate cancer patients and to give them a chance to discuss the issues with peers and experts. You can learn more about the conference here.

ABOUT THE AUTHOR

R. Jonathan Henderson, MD

About The Author

R. Jonathan Henderson, MD

R. Jonathan Henderson, MD, is a urologist with Arkansas Urology in Little Rock, Arkansas. He obtained a BS in microbiology from Louisiana State University (LSU) in Baton Rouge. After receiving his MD from LSU Medical Center (LSUMC) in Shreveport, he then completed his internship and residency in urology at LSUMC Hospital. During this time, he also authored a number of papers and presentations. Dr. Henderson spent the next six years in practice in Alabama, where he specialized in laparoscopy and treating disorders of the female bladder. During this time, he served as a representative of Alabama in the Southeastern Section of the American Urology Association. He also served as an assistant clinical professor of urology at the University of Alabama in Tuscaloosa. Dr. Henderson focuses his practice primarily on robotic surgeries and the treatment of prostate cancer. He is certified by the American Board of Urology. He is a member of the American Urologic Association, the Shreveport Medical Society, the Louisiana State Medical Society, the Society of Laparoscopic Surgeons, and the Alpha Omega Alpha Medical Honor Society. He is past-president of the Large Urology Group Practice Association (LUGPA) and has served on the Board of Directors since 2011.

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