Sanjay G. Patel, MD, presented “Urinary Markers in NMIBC: What’s New?” during the 3rd Annual International Bladder Cancer Update on January 23, 2019 in Beaver Creek, Colorado.
How to cite: Patel, Sanjay G. “Urinary Markers in NMIBC: What’s New?” January 23, 2019. Accessed Sep 2020. https://grandroundsinurology.com/urinary-markers-in-nmibc-whats-new/
Urinary Markers in NMIBC: What’s New? – Summary
Sanjay G. Patel, MD, defines challenges in the detection and surveillance of bladder cancer when using FDA-approved biomarkers. He then evaluates newer DNA methylation- , DNA mutations- , and mRNA-based biomarkers and their ability to account for the limitations of traditional markers.
The diagnosis and surveillance of bladder cancer predominantly relies on the use of cystoscopic evaluation in the clinic/operating room setting. However, cystoscopic evaluation has its own limitations, such as operator dependence, invasiveness, and difficulty in adequate bladder evaluation in the context of inflammation, small tumor, or carcinoma in situ. Urinary biomarkers have the potential to further inform diagnosis, risk stratification, and prognostication of patients with bladder cancer.
Traditional FDA-approved available biomarkers also have limitations, namely worse specificity compared to urine cytology, with modest improvement sensitivity. Newer urinary biomarkers rely on DNA methylation, DNA mutations, and mRNA. These show promise, and may better guide clinical decision-making in the diagnosis and surveillance of bladder cancer.
This presentation will review the performance and indications of historically FDA-approved, cell-based and protein-based biomarkers, comparing them to the newer biomarkers for patients with bladder cancer.
About the International Bladder Cancer Update
The International Bladder Cancer Update (IBCU) is an annual one-day CME conference focused on bladder cancer treatment updates. IBCU takes place during its sister conference, the International Prostate Cancer Update (IPCU). The conference’s faculty consists of international experts, and the event caters to urologists, urologic oncologists, and other healthcare professionals. In addition to didactic lectures, IBCU features interactive discussions, a panel roundtable, debates, and case presentations. Dr. Patel presented this lecture during the 3rd IBCU in 2019. Please visit this page in order to learn more about future IBCU meetings.