Brachytherapy and Focal Therapy Outcomes
Richard G. Stock, MD, Professor of Radiation Oncology and Director of Genitourinary Radiation Oncology at the Icahn School of Medicine at Mount Sinai in New York City, discusses focal therapy and brachytherapy. He outlines the rationale for focal therapy, reviews patient selection, and provides an extensive evaluation of the supporting evidence. For the small percentage of patients that may not have bilateral, multifocal disease, partial gland treatment can reduce morbidity and leave open future partial gland treatment options, should they become necessary. In general, patients in most studies examining focal therapy have unilateral disease, an MRI detectable lesion, Gleason score of <=7, and PSA <= 10ng/ml. Dr. Stock considers the types of focal therapy such as cryotherapy, high-intensity focused ultrasound (HIFU), and brachytherapy, highlighting the importance of treating the margin surrounding the tumor in any focal therapy. He then describes focal low dose rate brachytherapy and provides recommendations including a preplan and real-time ultrasound to ensure accuracy and minimize side effects. Lastly, Dr. Stock reviews data analyzing changes in morbidity, erectile function, and quality of life in whole gland and hemigland treatment plans.
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