Rana R. McKay, MD, presented “Trials in Neoadjuvant Therapy for Patients with High-Risk Localized Prostate Cancer​” for the Grand Rounds in Urology audience in October 2020.

Presentation Summary:

Rana R. McKay, MD, Associate Professor of Medicine at the University of California, San Diego, and Co-Leader of the Genitourinary Oncology Disease Team at the Moores Cancer Center, discusses neoadjuvant hormonal therapy for patients with high-risk localized prostate cancer. Neoadjuvant therapy has been shown to be beneficial to patients with breast, rectal, bladder, and other cancers, but historic neoadjuvant trials in prostate cancer have had limited long-term follow-up and have failed to systematically evaluate pathologic response. More recent trials are seeking to remedy these gaps, and results from a recent phase 2 trial indicate that a subset of high-risk patients do benefit greatly from intense neoadjuvant hormonal therapy. Dr. McKay explains that the phase 3 PROTEUS trial, which is currently recruiting, will hopefully allow researchers to better define exceptional responders and non-responders, identify intermediate pathologic endpoints, and figure out how best to integrate imaging and tissue biomarkers to guide neoadjuvant therapy selection for prostate cancer patients.

Q&A Summary:

E. David Crawford, MD, Editor-in-Chief of Grand Rounds in Urology and Professor of Urology at the University of California, San Diego, discusses neoadjuvant therapy for high-risk localized prostate cancer with Rana R. McKay, MD, Associate Professor of Medicine at the University of California, San Diego, and Co-Leader of the Genitourinary Oncology Disease Team at the Moores Cancer Center, following her presentation on recent trials in this area. They consider such topics as the potential of biomarkers to help some men avoid a surgical resection, the inevitability of therapy resistance in some patients, the potential of ADT alone to cure some patients of prostate cancer, and the comparative value of combination therapies versus monotherapies, among others.

How to cite: McKay, Rana R. “Trials in Neoadjuvant Therapy for Patients with High-Risk Localized Prostate Cancer” October 2020. Accessed Jan 2021. https://grandroundsinurology.com/trials-in-neoadjuvant-therapy-for-patients-with-high-risk-localized-prostate-cancer/