University of Southern California

WSAUA 2025: External Validation of an AI-Based Digital Pathology Model (MMAI) for Post-Prostatectomy Prognosis

This UCSF-validated AI digital pathology model predicts long-term prostate cancer outcomes after radical prostatectomy using routine H&E slides. The MMAI system independently forecasted metastasis, progression, and cancer-specific mortality, offering a faster, lower-cost alternative to genomic classifiers and supporting more precise post-surgical risk stratification.

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WSAUA 2025: Micro-Ultrasound (Micro-US), MRI, and PSMA PET in Prostate Cancer: Whole-Mount Correlation Study

Dr. Brisbane’s whole-mount correlation study compares micro-ultrasound (Micro-US), multiparametric MRI, and PSMA PET for detecting and staging prostate cancer. Results show Micro-US performs comparably to MRI for lesion detection, while MRI remains superior for assessing extracapsular extension. PSMA PET adds complementary but not superior diagnostic value.

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Energy Selection Ablative Technologies for Focal Therapy

Andre Abreu, MD, delves into energy modalities for focal therapy in prostate cancer, presented with a comprehensive and practical approach. This 16-minute presentation explores multiple energy options, including cryoablation, high-intensity focused ultrasound (HIFU), irreversible electroporation (IRE), laser ablation, and microwave ablation. Dr. Abreu emphasizes the importance of aligning energy selection with institutional expertise and patient-specific factors.

Patient-specific considerations guide technology selection, including rectal wall thickness and proximity to critical structures. Transition zone lesions benefit from tools like aqua ablation, while anterior lesions present challenges for certain devices. The speaker emphasizes the need for personalized management, integrating oncologic characteristics with procedural capabilities.

Dr. Abreu optimistically frames the future of focal therapy, with ongoing trials like vapor ablation and the potential for low-dose radiation therapy combined with IRE promising advancements. He calls for practical recommendations and an invitation for ongoing exploration in the evolving field of prostate cancer management.

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