Next Gen Microbiome

Section Editors

J. Curtis Nickel, MD, FRCSC

A. Lenore Ackerman, MD, PhD


Microbiome and Urologic Infections

Dedicated to the memory of microbiome research pioneer Vladimir Mouraviev, MD, PhD

There is an abundance of evidence that the human microbiome plays an important and nuanced role in controlling human health, including metabolism, immunity, pain, psychological state, and cancer. The recent discovery of the human genitourinary microbiome’s existence has led to the investigation of its role in mediating the pathogenesis of urinary tract infections, urologic pain syndromes, lower urinary tract symptoms, urolithiasis, and genitourinary malignancies like bladder, kidney, and prostate cancers. Furthermore, although it is largely recognized that members of the gastrointestinal microbiota are actively involved in drug metabolism, new studies demonstrate additional roles of the gastrointestinal microbiota (and their communication with the urinary microbiome) in dictating treatment response for urologic conditions, such as cancer.

There is now a host of evidence for a unique genitourinary (GU) microbiome. Translating microbiome research into clinical action will require incorporation of microbiome surveillance into ongoing and future clinical trials, as well as an expansion of studies to include metagenomic sequencing and metabolomics. In this learning center, we will review the most current research investigating a link between the gut and genitourinary microbiome and urologic disease. We will also focus on urologic infections and improving our understanding and treatment of them.

This learning center will provide information about our current and evolving state of knowledge with respect to our microbiome and its clinical impact on urologic disease. Our hope is that this expanding awareness of our urology microbiome will allow us to present clinically meaningful management strategies for the practicing physician.





New Advances in Penile Implant Infections Detection in 2022

A. Lenore Ackerman, MD, PhD, discusses new advances in penile implant infections detection with Gerard D. Henry, MD.

Fear and Frustration Among Women with Recurrent UTIs

A. Lenore Ackerman, MD, PhD, Ja-Hong H. Kim, MD, and Victoria C. Scott, MD, discuss a survey of women with recurrent UTIs.
Dr. Chung - Genitourinary Implants DNA Sequencing

Next Generation DNA Sequencing for Genitourinary Implants

Paul H. Chung, MD, discusses infection of genitourinary implants & how next-generation DNA sequencing can be used to manage device infection.
Dr. Gilbert rUTI

Covert Pathogenesis in the Urinary Tract

In a conversation with A. Lenore Ackerman, MD, PhD, Section Editor of the Next Generation Microbiome and Urologic Infection Learning Center on Grand Rounds in Urology, Nicole M. Gilbert, PhD, an instructor in the Department of Pediatrics at Washington University School of Medicine, discusses her research linking urogenital microbes to recurrent urinary tract infection (rUTI).
Dr. Le - Molecular Diagnostics Recurrent UTI

Practical Considerations for the Use of Molecular Diagnostics for Diagnosis and Management of Recurrent UTI

Ngoc-Bich “Nikki” Phan Le, MD, a urologist specializing in female pelvic medicine and reconstructive surgery at the Austin Diagnostic Clinic, and A. Lenore Ackerman, MD, PhD, Assistant Professor of Surgery, Urology, and Pelvic Medicine and Reconstructive Surgery at Cedars-Sinai Medical Center and Section Editor of the Next Generation Microbiome and Urologic Infection Learning Center on Grand Rounds in Urology, discuss how to effectively use molecular diagnostics to help in the process of diagnosing and managing recurrent UTIs.
Dr. Henry - Next Generation Sequencing

UPDATED: Next-Generation Sequencing of DNA in Prosthetic Urology: Promising Early Results

Gerard D. Henry, MD, a urologist with Ark-La-Tex Urology in Bossier City, Louisiana, discusses pathogen identification using next generation sequencing (NGS) in a urology-based setting. He goes on to describe the utility of PCR+NGS, discusses several case-studies demonstrating its superior performance compared to traditional culture, and presents the results of a single-center study demonstrating the benefit of using NGS vs traditional culture for pathogen identification in 101 patients after IPP.

The Implications of the Microbiome on Stone Pathophysiology, Stone Prevention and Novel Diagnostics

Manoj Monga, MD, and Aaron W. Miller, PhD, discuss the effect of the microbiome of the gut and urinary tract on the development and prevention of stone disease. Dr. Miller discusses research into oxalate metabolism in the gut that can lead to kidney stones, how the bacteria lactobacillus crispatus may reveal clues about metabolites that can help prevent the incidence of stones, as well as a strain of E. coli that may be connected to their increase.
Highlights of the Best Posters at EAU 2019 - Focus on Next Generation Sequencing

Highlights of the Best Posters at EAU 2019 – Focus on Next Generation Sequencing

Vladimir Mouraviev, MD, PhD, will soon become the section editor of Grand Rounds in Urology’s soon-to-be released Next Generation Learning Center in Microbials. The European Association of Urology (EAU) will honor Dr. Muraviev this weekend during their annual meeting. The EAU has accepted two of his posters to present during their Expert-Guided Poster Tour session.
What the Urologist Should Know

Prostate Inflammation and Prostate Cancer: What do I need to know?

Dr. J. Curtis Nickel, MD, FRCSC, explains the relationship between acute and chronic inflammation of the prostate and prostate cancer risk, citing data from the REDUCE trial. He also discusses prostate cancer risk factors, including tumor volume, number of positive cores, and prostate atrophy.



J. Curtis Nickel, MD, FRCSC
Queen’s University
Kingston, ON, Canada
Dr. Nickel’s research covers inflammatory, benign prostate and pain diseases of the urinary tract. He has over 550 publications, is on the editorial board of eight Urology journals, editor of the AUA Update Series, presented in 45 countries, funded by US NIH and Canadian CIHR and was awarded a CIHR Tier I Canada Research Chair (until 2021), AUA Distinguished Contribution Award and SIU Academy Award. He is currently Immediate Past-President of the Canadian Urological Association.
A. Lenore Ackerman, MD, PhD
Cedars-Sinai Medical Center
David Geffen School of Medicine at UCLA Health
Los Angeles, California

Dr. Ackerman is Assistant Professor of Surgery, Urology and Pelvic Medicine and Reconstructive Surgery at Cedars-Sinai Medical Center, as well as Adjunct Assistant Professor of Urology in the Department of Surgery, Division of Urology at the David Geffen School of Medicine at UCLA Health. Her current research focuses on the role of host-microbe interactions in the etiology of benign lower urinary tract disorders. She now specializes in the treatment of incontinence, voiding dysfunction, and pelvic floor disorders at Cedars-Sinai Medical Center in Los Angeles.