Next Gen Microbiome

Section Editors

J. Curtis Nickel, MD, FRCSC



A. Lenore Ackerman, MD, PhD


NEXT GENERATION

Microbiome and Urologic Infections

Dedicated to the memory of microbiome research pioneer Vladimir Mouraviev, MD, PhD

There is an abundance of evidence that the human microbiome plays an important and nuanced role in controlling human health, including metabolism, immunity, pain, psychological state, and cancer. The recent discovery of the human genitourinary microbiome’s existence has led to the investigation of its role in mediating the pathogenesis of urinary tract infections, urologic pain syndromes, lower urinary tract symptoms, urolithiasis, and genitourinary malignancies like bladder, kidney, and prostate cancers. Furthermore, although it is largely recognized that members of the gastrointestinal microbiota are actively involved in drug metabolism, new studies demonstrate additional roles of the gastrointestinal microbiota (and their communication with the urinary microbiome) in dictating treatment response for urologic conditions, such as cancer.

There is now a host of evidence for a unique genitourinary (GU) microbiome. Translating microbiome research into clinical action will require incorporation of microbiome surveillance into ongoing and future clinical trials, as well as an expansion of studies to include metagenomic sequencing and metabolomics. In this learning center, we will review the most current research investigating a link between the gut and genitourinary microbiome and urologic disease. We will also focus on urologic infections and improving our understanding and treatment of them.

This learning center will provide information about our current and evolving state of knowledge with respect to our microbiome and its clinical impact on urologic disease. Our hope is that this expanding awareness of our urology microbiome will allow us to present clinically meaningful management strategies for the practicing physician.

PLATINUM LECTURES
 
Dr. Siddiqui - OAB UUI
Overactive Bladder (OAB) / Urge Urinary Incontinence (UUI) & the Urinary Microbiome

Nazema Y. Siddiqui, MD, MHSc, presented “Overactive Bladder (OAB) / Urge Urinary Incontinence (UUI) & the Urinary Microbiome” for the Grand Rounds in Urology audience in July 2020.

Infection and Prostate Cancer “The Old Story”

J. Curtis Nickel, MD, presented this lecture during the 30th Annual International Prostate Cancer Update on January 23, 2020, in Avon, Colorado.

Next Generation Sequencing of Microbiomes in Urine Samples of Prostate Cancer Patients

Priya N. Werahera, PhD, presented this lecture during the 30th Annual International Prostate Cancer Update on January 23, 2020, in Avon, Colorado.

Dr. Anger - Recurrent Urinary Tract Infections
Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline 2019

Jennifer T. Anger, MD, MPH, and A. Lenore Ackerman, MD, PhD, presented “Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline 2019” for the Grand Rounds in Urology audience in May, 2020.

NEED TO KNOW

NGS+PCR – The Key to Clearing Chronic Urological Infections

Rick Martin, presented this lecture during the 30th Annual International Prostate Cancer Update on January 23, 2020, in Avon, Colorado.

ADDITIONAL LECTURES

ADDITIONAL RESOURCES

SECTION EDITORS

J. Curtis Nickel, MD, FRCSC
Queen’s University
Kingston, ON, Canada
Dr. Nickel’s research covers inflammatory, benign prostate and pain diseases of the urinary tract. He has over 550 publications, is on the editorial board of eight Urology journals, editor of the AUA Update Series, presented in 45 countries, funded by US NIH and Canadian CIHR and was awarded a CIHR Tier I Canada Research Chair (until 2021), AUA Distinguished Contribution Award and SIU Academy Award. He is currently Immediate Past-President of the Canadian Urological Association.
A. Lenore Ackerman, MD, PhD
Cedars-Sinai Medical Center
David Geffen School of Medicine at UCLA Health
Los Angeles, California

Dr. Ackerman is Assistant Professor of Surgery, Urology and Pelvic Medicine and Reconstructive Surgery at Cedars-Sinai Medical Center, as well as Adjunct Assistant Professor of Urology in the Department of Surgery, Division of Urology at the David Geffen School of Medicine at UCLA Health. Her current research focuses on the role of host-microbe interactions in the etiology of benign lower urinary tract disorders. She now specializes in the treatment of incontinence, voiding dysfunction, and pelvic floor disorders at Cedars-Sinai Medical Center in Los Angeles.