Wayne Brisbane, MD, presented “Artificial Intelligence for Improving Prostate Cancer Management” during the 8th Global Summit on Precision Diagnosis and Treatment of Prostate Cancer on October 8, 2024.
How to cite: Brisbane, Wayne. “Artificial Intelligence for Improving Prostate Cancer Management.” October 8, 2024. Accessed Feb 2025. https://grandroundsinurology.com/artificial-intelligence-for-improving-prostate-cancer-management/
Artificial Intelligence for Improving Prostate Cancer Management – Summary
In this 9-minute presentation, Wayne Brisbane, MD, explores the integration of AI in focal therapy for prostate cancer management at UCLA. Dr. Brisbane begins by outlining the historical overtreatment of prostate cancer and the evolving efforts to refine management through advanced imaging modalities and AI-based tools. He highlights the role of Unfold AI, a system designed to estimate tumor margins and volumes using multiparametric MRI, biopsy data, and patient demographics.
Multifocal disease and margin estimation challenge focal therapy. Dr. Brisbane explains how AI helps address this by creating detailed cancer estimation maps. He presents data showing the correlation between AI-predicted tumor volumes and clinical outcomes.
Clinical examples underscore the AI’s ability to improve margin estimation, identify residual disease risks, and refine patient selection. A comparison of AI-based predictions with observed surgical margins confirms its reliability, outperforming traditional metrics like grade groups and PSA density. Dr. Brisbane also discusses the utility of Unfold AI in identifying patients with extra-capsular extension who might otherwise be unsuitable for focal therapy.
The Global Summit on Precision Diagnosis and Treatment of Prostate Cancer is a unique multi-disciplinary forum organized to inform the key health care stakeholders about the emerging advances in clinical case and research and create a consensus-based vision for the future of precision care and educational and research strategy for its realization. The mission of the Summit is to fill the currently existing gap between the key experts of in vivo imaging, the world authorities in the in vitro fluid- and tissue-based molecular diagnostics, including genomics, and thought leaders in the development of novel observation strategies (e.g., active surveillance, or AS) and therapeutic interventions.
ABOUT THE AUTHOR
Wayne G. Brisbane, MD, is an assistant professor of urology. Dr. Brisbane received his medical degree from Loma Linda University School of Medicine. He completed a General Surgery internship and Urology residency at the University of Washington. He completed his Urologic Oncology fellowship at UCLA, focusing on prostate cancer.
