How to cite: Daneshmand S and Shah PH. Beyond Symptom Management: Exploring Hydration as a Proactive Strategy to Improve the INLEXZO™ Patient Experience. Grand Rounds in Urology. July 2026. Accessed Oct 2026. https://grandroundsinurology.com/beyond-symptom-management-exploring-hydration-as-a-proactive-strategy-to-improve-the-inlexzo-patient-experience/
Summary
Sia Daneshmand, MD, Professor of Urology, University of Southern California Keck School of Medicine, Los Angeles, California, speaks with Paras H. Shah, MD, Urologic Oncologist, Mayo Clinic, Rochester, Minnesota, about INLEXZO™, an indwelling intravesical drug-delivery approach for patients with BCG-unresponsive carcinoma in situ. They emphasize hydration as a proactive strategy for managing urinary symptoms and improving the patient experience.
The discussion focuses on the device’s physical behavior within the bladder.
The INLEXZO™ device floats rather than remaining fixed to one area of the bladder wall. Hydration helps maintain a fuller bladder, allowing the device to remain floating and reducing side effects, improving the patient experience.
Urgency, frequency, and other irritative voiding symptoms can affect patients during treatment, making proactive management and expectation setting important components of the treatment process.
The doctors emphasize the importance of clear communication and patient education and share additional strategies to address bladder irritation, including medications and adequate hydration, to improve the patient experience.
ABOUT THE AUTHOR
Sia Daneshmand, MD, is a Professor of Urology and Medicine (Oncology) with a Clinical Scholar designation at the University of Southern California in Los Angeles. He serves as the Director of Urologic Oncology and the Fellowship Director for the Society of Urologic Oncology (SUO) Fellowship. His primary clinical interests include bladder cancer, testicular cancer, and advanced kidney cancer.
Paras H. Shah, M.D., is an Assistant Professor of Urology at Mayo Clinic College of Medicine and Science and a urologic oncologist at Mayo Clinic in Rochester, Minnesota. His clinical practice focuses on the surgical management of genitourinary malignancies, including prostate, bladder, kidney, and ureteral cancers.
