Jelle Barentsz, MD, PhD, presented “Recent Advancements in PI-RADS: mpMRI vs. bpMRI” during the virtual 5th Global Summit on Precision Diagnosis and Treatment of Prostate Cancer in September 2021.
How to cite: Barentsz, Jelle. “Recent Advancements in PI-RADS: mpMRI vs. bpMRI.” September 2021. Accessed Nov 2024. https://grandroundsinurology.com/recent-advancements-in-pi-rads-mpmri-vs-bpmri/
Recent Advancements in PI-RADS: mpMRI vs. bpMRI – Summary
Jelle Barentsz, MD, PhD, Professor of Radiology at the Nijmegen Medical Center of Radboud University in Nijmegen, The Netherlands, begins his talk on recent advancements in the prostate imaging-reporting and data system (PI-RADS) by asserting the value of local magnetic resonance imaging (MRI) in the diagnosis of prostate cancer. He cites the 2019 European Association of Urology (EAU) guidelines, which recommend performing a prostate MRI before biopsy, and points out that this results in 2,000,000 MRIs annually. He asserts there is a need for fast MRI, citing a PI-RADS committee position on MRI without the use of gadolinium (Gd)-based contrast medium (biparametric MRI, or bpMRI) which suggests that if certain prerequisites are satisfied, bpMRI may offer a fast MRI option for some patients. Dr. Barentsz then cites three studies. The first compared screenings using multi-parametric MRI (mpMRI) with bpMRI and found the prostate cancer detection rate was identical (but it failed to specify which patients had insignificant vs. clinically-significant prostate cancer [csPCa]). The second study compared single-plane (or “fast”) bpMRI vs. mpMRI and concluded mpMRI found nine percent more csPCa; however Dr. Barentsz points out the study was underpowered and used an older technique, a 1.5T endorectal coil (ERC) MRI. Dr. Barentsz explores data from the third study, which found that mpMRI and fast bpMRI demonstrated equal sensitivity in finding csPCa, at 95 percent. He outlines the pros and cons of the fast bpMRI, emphasizing that for less-experienced radiologists, the procedure increases uncertainty. Dr. Barentsz explains that the PI-RADS committee concludes there is a need to have both unenhanced MRI and contrast-enhanced MRI approaches available for prostate-cancer diagnosis. Dr. Barentsz then turns to the issue of costs, showing data comparing the direct cost of mpMRI, bpMRI, and “fast” bpMRI, specifying that mpMRI is more than twice as costly as “fast” bpMRI. Dr. Barentsz asserts that dynamic contrast-enhanced (DCE)-MRI is a better choice for patients with a previous negative bpMRI with persistent clinical suspicion, DWI-artifacts (e.g., hip prosthesis), and for doctors with a lower level of expertise. Dr. Barentsz then explains situations when bpMRI (no DCE) may be an appropriate choice, such as in a low-risk (screening) population or when there is a high chance of having significant prostate cancer. Dr. Barentsz concludes his talk by stating that bpMRI can be effective for very skilled prostate radiologists. He reiterates that DCE helps find small tumors, reduces uncertainty, and increases confidence. He also states that the prerequisites for bpMRI are good quality imaging, and specifies the need for objective quality assessment and control as well as training and certification.
The Virtual Global Summit on Precision Diagnosis and Treatment of Prostate Cancer brings together key international opinion leaders of every clinical subspecialty involved in patient care. This event is an integral part of the AdMeTech Foundation’s Annual Summit, which was established in 2016 and became seminal in shaping the state of the art and future vision for precision care. The goal of this event is three-fold: 1) Educating the key stakeholders; 2) Supporting a sustained cross-disciplinary dialogue and consensus on the best emerging clinical practices and research priorities; and 3) Expediting clinical adoption of promising novel diagnostics and therapeutics. For more educational activities from this virtual event, visit our collection page.
ABOUT THE AUTHOR
Jelle Barentsz, MD, PhD, is a Professor of Radiology at the Nijmegen Medical Center of Radboud University in Nijmegen, The Netherlands. He is an internationally recognized researcher known for developing, validating, and implementing new MRI techniques in oncology. He is also the Chair of the Prostate MR-Reference Center, Founding Member and Past-President of the International Cancer Imaging Society, and Past-President of the European Society of Urogenital Radiology (ESUR). In 1980, he earned his MD from Utrecht University. In 1990, he earned his PhD in medical research on MRI of the urinary bladder from Radboud University Nijmegen. Since then, he has contributed to almost 300 peer-reviewed publications. One of his notable contributions involves initiating PI-RADS and, along with ESUR and the American College of Radiology, making the system a world standard, thereby enabling early selective detection of aggressive prostate cancer. Also, he helped revive Combidex-MRI, which can detect 1.5 mm lymph node metastases of any cancer.
He has been decorated as a “Knight in the Order of the Dutch Lion.” In addition, he has been awarded the Wertheim Salomonson Medal, the SAR Lifetime Achievement Award, the Dutch Cancer Society’s Queen Wilhelmina Research Award, and the SCBTMR Lauterbur Award.
