Benjamin R. Lee, MD, MBA, presented “Management Of High-Risk Renal Cell Carcinoma Update 2024” during the 31st Annual Perspectives in Urology: Point-Counterpoint, on October 18, 2024, in Scottsdale, Arizona.
How to cite: Lee, Benjamin R. “Management Of High-Risk Renal Cell Carcinoma Update 2024.” October 18, 2024. Accessed Feb 2025. https://grandroundsinurology.com/management-of-high-risk-renal-cell-carcinoma-update-2024/
Management Of High-Risk Renal Cell Carcinoma Update 2024 – Summary
Benjamin R. Lee, MD, MBA, provides a comprehensive analysis of current strategies and advancements in managing renal cell carcinoma (RCC). In this 22-minute presentation, Dr. Lee begins with an overview of AUA guidelines on nephron-sparing surgery, emphasizing partial nephrectomy as the preferred approach for small renal masses under four centimeters. Radical nephrectomy remains reserved for cases with high tumor complexity or significant oncologic potential.
Dr. Lee highlights racial disparities in RCC presentation, with African Americans showing a higher incidence of papillary RCC and Native Americans experiencing earlier onset and higher mortality rates, potentially linked to genetic and environmental factors. Emerging trends in robotic-assisted partial nephrectomy are explored, demonstrating its efficacy in treating larger tumors with reduced ischemia times and improved recovery metrics.
Dr. Lee reviews the outcomes of redo partial nephrectomies, ablations, and completion nephrectomies for recurrent disease, outlining their oncologic and renal implications. Updates on genetic counseling underscore its importance for patients with early-onset, bilateral, or familial RCC.
Dr. Lee notes the shift toward immunotherapies and PD-1 inhibitors as preferred options. He underscores the importance of personalized care and multidisciplinary collaboration, advocating for the integration of evolving surgical techniques and systemic therapies to optimize outcomes for RCC patients.
About the 31st Annual Perspectives in Urology: Point Counterpoint conference: Presented by Program Chair and Grand Rounds in Urology Editor-in-Chief E. David Crawford, MD, this conference brought together leading experts in urology, medical oncology, and radiation oncology to discuss and debate the latest topics in genitourinary cancers, primarily prostate cancer and bladder cancer. This interactive conference offered topical lectures, pro/con debates, interesting-case presentations, interactive panel discussions, and interactive audience and faculty networking.
ABOUT THE AUTHOR
Dr. Benjamin Lee, Professor & Chief (Interim) of Urology at the University of Arizona College of Medicine has focused his career on advancing new treatments for renal cell carcinoma as well as calculus disease, while developing new technologies & techniques for Urologic Oncology & Endourology. He is author or co-author of more than 200 manuscripts, book chapters, videos and abstracts.
