Mira Keyes, MD, FRCPC, FABS, presented “ADT and Radiation” during the 35th International Prostate Cancer Update conference on February 9, 2025, in Vail, Colorado.
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How to cite: Keyes, Mira. “ADT and Radiation.” February 9, 2025. Accessed Jul 2025. https://grandroundsinurology.com/adt-and-radiation/
ADT and Radiation – Summary
Mira Keyes, MD, FRCPC, FABS, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, discusses the role of androgen deprivation therapy (ADT) combined with radiation for prostate cancer treatment. In this 13-minute presentation, Dr. Keyes offers valuable insights into balancing ADT benefits with potential harms to improve outcomes in prostate cancer management.
Dr. Keyes highlights data from randomized controlled trials, emphasizing that adding ADT to radiation significantly improves overall survival, particularly in high-risk patients. While longer ADT durations yield better outcomes, she warns of substantial side effects such as cognitive dysfunction, osteoporosis, and cardiovascular risks. She also explores the potential advantage of using ADT antagonists over agonists. The discussion underscores the importance of individualized treatment, advising careful consideration of patient age, comorbidities, and cardiac history.
Dr. Keyes highlights strategies to minimize ADT use. Emphasizing the need for multidisciplinary care, she recommends referring patients with cardiovascular risks to cardiologists for optimal management. Her presentation offers valuable insights into balancing ADT benefits with potential harms to improve outcomes in prostate cancer management.
About the 35th International Prostate Cancer Update:
The International Prostate Cancer Update (IPCU), is a multi-day, CME-accredited conference focused on new developments in prostate cancer treatment, diagnosis, and prevention. IPCU 35 will feature lectures, interactive discussions, panel roundtables, debates, and case reports. This conference is led by expert physicians and is designed for urologists, medical oncologists, radiation oncologists, and other healthcare professionals involved in the diagnosis and treatment of prostate cancer.
The goal of this educational program is to equip healthcare professionals involved in the diagnosis and treatment of prostate cancer with the up-to-date clinical knowledge and tools they need to best treat their patients. The program will discuss the treatment of prostate cancer from diagnosis to treating advanced and metastatic disease. The conference aims to give physicians exposure to a comprehensive review of treating prostate cancer patients and to give them a chance to discuss the issues with peers and experts. You can learn more about the conference here.
ABOUT THE AUTHOR
Mira Keyes, MD, FRCPC, FABS, is a Clinical Professor at the University of British Columbia (UBC) and a radiation oncologist at the Vancouver Centre of the British Columbia Cancer Agency (BCCA). Dr. Keyes has a wide range of research interests, including Prostate Brachytherapy, Genito-Urinary Oncology, Breast Cancer, Postgraduate Medical Education, and Patient Communication.
Dr. Keyes received her MD at the University of Novi Sad in Yugoslavia, Serbia. Dr. Keyes then received her FRCPC Radiation Oncology from the Royal College of Physicians of Canada. Dr. Keyes completed her fellowship at the Royal College of Physicians of Canada for Radiation Oncology, in the Vancouver Cancer Center.
