J. Curtis Nickel, MD, FRCSC, presented “An Introduction to the Urinary Microbiome: Part 2 – Impact on Urinary Disease” for the Grand Rounds in Urology audience in September 2020.
How to cite: Nickel, J. Curtis. “An Introduction to the Urinary Microbiome: Part 2 – Impact on Urinary Disease” September 2020. Accessed Nov 2024. https://grandroundsinurology.com/an-introduction-to-the-urinary-microbiome-part-2-impact-on-urinary-disease/
An Introduction to the Urinary Microbiome: Part 2 – Impact on Urinary Disease – Summary:
In the second lecture of a three-part foundational series for Grand Rounds in Urology’s Next Generation Microbiome and Urologic Infections Learning Center, J. Curtis Nickel, MD, FRCSC, Professor of Urology at Queen’s University in Ontario, Canada, discusses how changes to the urinary microbiome, which he previously described as helping maintain urinary health, can contribute to the development of urinary disease. Dr. Nickel summarizes the findings of several studies that evaluate the impact of the microbiome on urologic chronic pelvic pain, observing that dysbiosis appears to be more important than any particular bacterium in the development of chronic prostatitis/chronic pelvic pain syndrome, female bladder pain, and female lower urinary tract symptoms (LUTS), although researchers have identified some candidate organisms. Dr. Nickel notes that the development of struvite stones and calcium oxalate stones are also associated with dysbiosis. He concludes by discussing the role of bacteria in urinary cancers, explaining that distinct microbiome patterns appear to be related to certain responses to bladder cancer, and that prostate cancer is often associated with prostate inflammation caused by bacterial infection, although the role of the microbiome in prostate cancer development has yet to be determined.
After watching, be sure to visit the other parts of this lecture series (linked below) and explore our learning center.
An Introduction to the Urinary Microbiome: Part 1 – A Primer
An Introduction to the Urinary Microbiome: Part 3- Manipulation for Urologic Health
ABOUT THE AUTHOR
Dr. Nickel is the Canada Research Chair in Urologic Pain and Inflammation and a Professor of Urology at Queen’s University in Kingston, Ontario. He is also a staff urologist at Kingston General Hospital. Dr. Nickel’s research covers inflammatory, benign prostate, and pain diseases of the urinary tract. He has over 550 publications, is on the editorial board of eight urology journals, serves as editor of the AUA Update Series, has presented in 45 countries, and is funded by the US NIH and Canadian CIHR. He has been awarded a CIHR Tier I Canada Research Chair (until 2021), as well as an AUA Distinguished Contribution Award and SIU Academy Award. He is currently Immediate Past-President of the Canadian Urological Association.
