PSMA Radiopharmaceuticals: Update 2023

A. Oliver Sartor, MD of Tulane University School of Medicine, presents on the use of prostate-specific membrane antigen (PSMA) radiopharmaceuticals in the treatment of prostate cancer in 2023. He provides a comprehensive overview of recent advancements, clinical applications, and future directions for PSMA-targeted therapies. He discusses the latest developments in PSMA-based imaging, highlighting the efficacy of PSMA PET/CT scans in detecting prostate cancer metastases with high sensitivity and specificity. Dr. Sartor emphasizes that these imaging techniques have revolutionized the staging and restaging of prostate cancer, enabling more accurate assessment of disease spread and guiding treatment decisions.

Dr. Sartor also covers therapeutic applications of PSMA radiopharmaceuticals, focusing on PSMA-targeted radioligand therapy (RLT). He presents data from recent clinical trials demonstrating the efficacy of PSMA RLT with agents such as lutetium-177 (Lu-177) PSMA-617 in patients with metastatic castration-resistant prostate cancer (mCRPC).

In conclusion, Dr. Sartor highlights the transformative impact of PSMA radiopharmaceuticals on the management of prostate cancer, underscoring the potential of PSMA-targeted radiopharmaceuticals to significantly enhance the detection and treatment of prostate cancer, offering new hope for patients with advanced disease.

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