Dr. Seth Lerner and Dr. Daniel Petrylak, both experts in the clinical area of bladder cancer, provide analysis of treating this common cancer and its future prospects.
Presentation:
In this issue of Grand Rounds in Urology, two leading experts in the clinical area of bladder cancer will provide analysis of treating this common cancer and its future prospects. According to recent statistics, bladder cancer is the fourth most common type of cancer in men and the eighth most common in women. Each year in the United States, more than 70,000 men and women combined are diagnosed with bladder cancer. More than 90% of patients with bladder cancer (both men and women) have a transitional cell cancer (TCC), and unfortunately current chemotherapeutic agents for advanced or metastatic disease rarely result in cure.. Additionally, bladder cancer is one of the most costly cancers to treat, more costly than lung cancer, more than breast cancer, and more costly than colon cancer. It is expected that the incidence of bladder cancer will continue to increase, and most of the surviving patients will require frequent follow up and treatment.
In the first article, Dr. Seth Lerner, from Baylor College of Medicine, discusses a number of challenges in managing localized disease , including intra- vesical therapy and endoscopic imaging. Since this field is moving fairly quickly, Dr. Lerner provides the reader with some tools that might answer the question as to why wouldn’t you want to see better at the time of cystoscopy. The discussion covers issues like fluorescence, narrow- band imaging, and optical coherence tomography as well as drug therapy, and we hope it will offer valuable ideas on how to provide a more complete diagno- sis and comprehensive therapy.
The second article is from Dr. Daniel Petrylak, from Columbia University, who provides his analysis a systemic approach to treatment. Of important emphasis is how understanding biology can help in the development of future clinical trials. Dan discusses adjuvant and neoadjuvant therapy, antiangiogentics agents, and the prospect of vaccines among the ongoing variety of approaches. His thorough review suggests there is an utmost need for collaborative clinical trials to find new ways to attack this difficult to treat and deadly disease.
Keywords: bladder cancer, localized disease, intra- vesical therapy, endoscopic imaging, cystoscopy, fluorescence, narrow-band imaging, optical coherence tomography, drug therapy, adjuvant therapy, neoadjuvant therapy, antiangiogentics agents, vaccines
How to cite: Lerner, Seth, and Daniel P. Petrylak. “Bladder Cancer: Advances in Diagnosis and Clinical Care.” Grand Rounds in Urology. January 19, 2015. Accessed Dec 2024. https://grandroundsinurology.com/bladder-cancer-lerner-petrylak-diagnosis/.
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ABOUT THE AUTHOR
Seth P. Lerner, MD, FACS, is Professor of Urology and Vice-Chair for Faculty Affairs in the Scott Department of Urology at the Baylor College of Medicine in Houston, Texas. He holds the Beth and Dave Swalm Chair in Urologic Oncology. Dr. Lerner is the Director of Urologic Oncology and the Multidisciplinary Bladder Cancer Program, also at Baylor.
Dr. Lerner earned his medical degree from the Baylor College of Medicine, completed a surgical internship at Virginia Mason Hospital in Seattle, and returned to Baylor for his residency training. He completed a two-year fellowship at the University of Southern California in Urologic Oncology and Reconstructive Surgery and joined the full-time Baylor faculty in 1992.
