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Neoadjuvant Therapy for High-Risk Prostate Cancer

Adam S. Kibel, MD, argues that, while it is common to debate the best intervention method for local prostate cancer, there also must be an emphasis on the systemic treatment of micro-metastatic disease in the interest of decreasing disease-specific death. He then reviews the impact of timing, duration, and intensity of systemic therapy on patient outcomes, focusing on four trials evaluating neoadjuvant therapy for high-risk prostate cancer.

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Management of Adverse Pathology after Radical Prostatectomy

Jason A. Efstathiou, MD, DPhil, reviews the results of randomized studies and large retrospective experiences evaluating the efficacy, safety, and timing of post-prostatectomy radiation. He discusses the role of androgen deprivation therapy in addition to radiation in the salvage postoperative setting, and the potential use of genomic and advanced imaging biomarkers in patient treatment selection.

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The Role of FSH in Prostate Cancer

Marc B. Garnick, MD, discusses whether or not follicle stimulating hormone (FSH) affects prostate cancer progression and cause adverse effects when used in combination with androgen deprivation therapy (ADT). He presents evidence for both the pro and con sides of this argument.

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