Steven S. Raman, MD presented “Integration of Histology, Genomics and Proteomics with MRI” during the 7th Global Summit on Precision Diagnosis and Treatment of Prostate Cancer on September 22, 2023.
How to cite: Raman, Steven S. “Integration of Histology, Genomics and Proteomics with MRI.” September 22, 2023. Accessed Dec 2024. https://grandroundsinurology.com/integration-of-histology-genomics-and-proteomics-with-mri/
Integration of Histology, Genomics and Proteomics with MRI – Summary
Steven S. Raman, MD, explores how histology, genomics, and proteomics with MRI revolutionize the diagnosis and treatment of prostate cancer. Histology provides critical insights into the pathological features of prostate cancer; genomics offers a deeper understanding of the genetic mutations and alterations that drive cancer progression; and proteomics sheds light on the protein expressions and interactions that occur within the tumor microenvironment. Raman asserts that each modality, while powerful on its own, gains significance when integrated with MRI prostate imaging.
He elaborates on the technological advancements and methodological innovations that facilitate this integration. Raman highlights how multi-parametric MRI (mpMRI) can be augmented with molecular data from histology, genomics, and proteomics to create a more comprehensive and nuanced diagnostic picture. Recent studies show significant improvements in the detection, characterization, and monitoring of prostate cancer, leading to more personalized and effective treatment strategies.
The Global Summit on Precision Diagnosis and Treatment of Prostate Cancer is a unique multi-disciplinary forum organized to inform the key health care stakeholders about the emerging advances in clinical case and research and create a consensus-based vision for the future of precision care and educational and research strategy for its realization. The mission of the Summit is to fill the currently existing gap between the key experts of in vivo imaging, the world authorities in the in vitro fluid- and tissue-based molecular diagnostics, including genomics, and thought leaders in the development of novel observation strategies (e.g., active surveillance, or AS) and therapeutic interventions.
ABOUT THE AUTHOR
Steven S. Raman, MD, is Clinical Professor of Radiology and Director of Prostate MR Imaging and Interventions at the David Geffen School of Medicine of the University of California, Los Angeles (UCLA). Dr. Raman is an expert in abdominal and pelvic imaging (CT, MRI, US, and X-Ray) and interventional radiology (image-guided procedures), especially in the area of tumor ablation and fibroid treatment. He is Director of the Abdominal Imaging Fellowship and Co-Director of the Fibroid Treatment Program, both at UCLA. Dr. Raman received his MD from the Keck School of Medicine at the University of Southern California, and then completed a fellowship in Radiological Sciences at the University of California, San Diego, as well as a residency in Radiological Sciences at UCLA. He is board-certified in diagnostic radiology.
