How to cite: Klotz, Lawrence. “Management of Disease Recurrence in Localized Prostate Cancer.” January 24, 2023. Accessed Dec 2024. https://grandroundsinurology.com/management-of-disease-recurrence-in-localized-prostate-cancer/
Management of Disease Recurrence in Localized Prostate Cancer – Summary
Laurence Klotz, MD, FRCSC, discusses the complexities surrounding salvage therapy and focal therapy. Dr. Klotz explores the challenges that arise when managing local failure after radiation, providing insights into the polarized perspectives on the significance of focal therapy. He highlights the striking similarities in disease control achieved through various modalities of salvage therapy, shedding light on the potential benefits of radiation in mitigating genitourinary (GU) and gastrointestinal (GI) toxicity.
Dr. Klotz emphasizes the need to redefine treatment goals in focal therapy, urging a shift towards preventing metastasis and mortality as primary objectives, rather than seeking complete cancer eradication. Furthermore, the presentation discusses the captivating concept of “invisible tumors” and their favorable genetic features, aligning with the emerging principles of image-based management and its integration with focal therapy, allowing for personalized, targeted treatments that hold promise for improved patient outcomes.
About The 33rd Annual International Prostate Cancer Update:
The International Prostate Cancer Update (IPCU), founded in 1990, is a multi-day CME conference focused on prostate cancer treatment updates with expert, international faculty. It is led by expert physicians and is designed for urologists, medical oncologists, radiation oncologists, and other healthcare professionals involved in the diagnosis and treatment of prostate cancer. The 33rd iteration of the meeting occurred January 22-25, 2023 in Vail, Colorado. To view more educational presentations from IPCU 33, visit our collection page.
ABOUT THE AUTHOR
Laurence Klotz, MD, FRCSC, is a professor of surgery at the University of Toronto and the Sunnybrook Chair of Prostate Cancer Research. Dr. Klotz was the founding editor-in-chief of both the Canadian Journal of Urology and the Canadian Urology Association Journal (CUAJ), and he is now editor emeritus of the CUAJ. Dr. Klotz obtained his medical degree and completed his residency at the University of Toronto. He was also a uro-oncology fellow at Memorial Sloan Kettering Cancer Center in New York.
Dr. Klotz has 550 peer review publications and eight books. He coined the phrase “active surveillance” and successfully championed this approach for men with favorable-risk prostate cancer against substantial resistance. He was the associate editor of the Journal of Urology, responsible for prostate cancer, for eight years. Dr. Klotz received the Queen’s Jubilee Medal for outstanding public service, the University of Toronto's Lister Prize, the Society of Urologic Oncology’s SUO Medal, the American Urological Association’s Richard Williams Award, the University of Toronto's Lifetime Achievement Award, the Canadian Urological Association Lifetime Achievement Award, and the Harold Warwick Award from the Canadian Cancer Society for “outstanding contributions to cancer control.” In 2015 he was inducted as a Member of the Order of Canada, Canada’s highest civilian award.
