Adam Cole, USAF, Col. MD, presents “TruCore.”
How to cite: Cole, Adam. “TruCore.” February 19, 2025. Accessed Feb 2025. https://grandroundsinurology.com/trucore/
TruCore – Summary
Adam Cole, USAF, Col. MD, an anatomic and clinical pathologist and Chief Science Officer of Truco Pathology, discusses how digital pathology transforms clinical practice, particularly in genitourinary pathology. In this 9-minute presentation, he introduces a fully digital lab solution that enhances tissue processing, tracking, and analysis. Replacing traditional biopsy vials with RFID-enabled biopsy boards maintains tissue orientation, minimizing fragmentation and improving tissue preservation. The transition to digital imaging allows pathologists to assess slides on computers or tablets, enhancing efficiency and diagnostic precision. Artificial intelligence aids in identifying cancerous regions, grading tumors in real time, and calculating tumor volume with high accuracy. AI-driven prognostic modeling incorporates nuclear morphology, chromatin structure, and tumor microenvironment, providing deeper insights beyond traditional Gleason grading. Integration with immunohistochemical staining further refines diagnosis, improving cancer detection rates from 45% to over 60%. The pathology report is designed for clinical utility, featuring structured findings, visual mapping, and critical comments for better decision-making. Future advancements in metabolomics will allow real-time assessment of tumor energy utilization, distinguishing between indolent and aggressive disease. These innovations offer clinicians enhanced tools for diagnosis, risk stratification, and treatment planning, ultimately improving patient care.
