Seth P. Lerner, MD, moderated “Updates in Upper Tract Urothelial Cancer” during the International Bladder Cancer Update 2021 virtual conference in April 2021.


How to cite: Lerner, Seth P. “Updates in Upper Tract Urothelial Cancer” April 2021. Accessed Jan 2022. https://grandroundsinurology.com/updates-in-upper-tract-urothelial-cancer/

Updates in Upper Tract Urothelial Cancer – Summary:

Seth P. Lerner, MD, Professor of Urology and holder of the Beth and Dave Swalm Chair in Urologic Oncology in the Scott Department of Urology at Baylor University, provides an update on recent trials and treatment options for upper tract urothelial cancer (UTUC). He begins with the OLYMPUS study, a phase III prospective study assessing treatment of low-grade disease with mitomycin gel, which found a complete response in 59% of patients. Dr. Lerner then outlines the rationale for neoadjuvant therapy, which is based, in part, on level 1 evidence for patients with muscle invasive bladder cancer, adding that it can help identify patients at increased risk for locally advanced or micrometastatic disease. Newer data shows a lower pathological stage in patients who were treated with neoadjuvant chemotherapy than patients treated without. He notes that the EAU recently updated its guidelines to strongly recommend adjuvant chemotherapy. Dr. Lerner reviews ECOG’s EA8141, a prospective phase II trial of neoadjuvant chemotherapy followed by surgery in high-risk UTUC, which found roughly a 14% overall pathological complete response rate after treatment. He then comments on Lynch Syndrome and the approval of Pembrolizumab for patients with unresectable or metastatic MSI high or MMR deficient solid tumors. This treatment should be considered in patients with a solitary kidney. Dr. Lerner concludes with a discussion of adjuvant therapy including an overview of the POUT trial.

About the International Bladder Cancer Update 2021 virtual conference:
The International Bladder Cancer Update (IBCU) is a CME conference focused on the diagnosis and treatment of bladder cancer. The conference offers medical professionals an opportunity to listen to updates from, and interact with, expert international faculty to improve knowledge and determine best treatment practices to improve patient outcomes. IBCU encompasses expert lectures, interactive discussions, a panel roundtable, debates, and case presentations. It is physician-led, multi-supported, and designed for urologists, urologic oncologists, and other healthcare professionals involved in the treatment of bladder cancer.