Taimur Shah, MD presented “Clinical Trials in Focal Therapy – Endpoint, Design, Updates” during the 2023 Frontiers in Oncologic Prostate Care and Ablative Local Therapy symposium on November 10, 2023, in Chicago, Illinois.
How to cite: Shah, Taimur. “Clinical Trials in Focal Therapy – Endpoint, Design, Updates.” November, 2023. Accessed Aug 2024. https://grandroundsinurology.com/clinical-trials-in-focal-therapy-endpoint-design-updates/
Clinical Trials in Focal Therapy – Endpoint, Design, Updates – Summary
Taimur Shah, MD, provides an in-depth analysis of clinical trials in focal therapy for prostate cancer, focusing on endpoints, design, and recent updates.
Dr. Shah emphasizes the importance of carefully defined endpoints in clinical trials for focal therapy, including oncologic control measures such as progression-free survival, biochemical recurrence rates, and cancer-specific mortality. Secondary endpoints typically assess functional outcomes, including urinary continence and sexual function, to gauge the impact on patients’ quality of life. These criteria are crucial for determining the effectiveness and safety of focal therapy compared to traditional treatments.
The design of clinical trials in focal therapy is discussed in detail. Dr. Shah highlights the need for robust methodologies, including randomized controlled trials (RCTs) and prospective cohort studies. He discusses the latest data on various focal therapy modalities, including high-intensity focused ultrasound (HIFU), cryoablation, and photodynamic therapy.
The presentation also addresses the challenges and limitations of current clinical trials. These include the need for standardized treatment protocols, variability in imaging and biopsy techniques, and the difficulty of conducting long-term follow-ups. Dr. Shah emphasizes the importance of continued research and collaboration among institutions to overcome these challenges and refine focal therapy approaches.
Frontiers in Oncologic Prostate Care and Ablative Local Therapy (FOCAL) is an outstanding program on prostate imaging, transperineal interventions, and ablative treatments for prostate cancer and benign prostatic hyperplasia. Bringing together community-based, academic, and industry partners, FOCAL offers lectures by world-renowned faculty and hands-on training workshops on in-office transperineal interventions, fusion-guided prostate ablation and state-of-the-art BPH management with novel technologies.
