Jana McHugh, MB Bch BAO (Hons), MRCPI, FFR, presented “Update on the PROFILE and IMPACT Studies” during the 8th Global Summit on Precision Diagnosis and Treatment of Prostate Cancer on October 8, 2024.
How to cite: McHugh, Jana. “Update on the PROFILE and IMPACT Studies.” October 8, 2024. Accessed Jan 2025. https://grandroundsinurology.com/update-on-the-profile-and-impact-studies/
Update on the PROFILE and IMPACT Studies – Summary
Jana McHugh, MB Bch BAO (Hons), MRCPI, FFR, discusses the IMPACT and PROFILE studies, which focus on prostate cancer risk and detection in genetically predisposed populations.
In this 11-minute presentation, McHugh shows that both studies emphasize early detection in genetically high-risk men, particularly BRCA mutation and Lynch syndrome carriers. Updated methodologies incorporate multi-ancestry PRS and expanded genetic sequencing to refine risk assessment and address disparities. These findings highlight the importance of precision screening in managing prostate cancer in diverse, high-risk populations.
The Global Summit on Precision Diagnosis and Treatment of Prostate Cancer is a unique multi-disciplinary forum organized to inform the key health care stakeholders about the emerging advances in clinical case and research and create a consensus-based vision for the future of precision care and educational and research strategy for its realization. The mission of the Summit is to fill the currently existing gap between the key experts of in vivo imaging, the world authorities in the in vitro fluid- and tissue-based molecular diagnostics, including genomics, and thought leaders in the development of novel observation strategies (e.g., active surveillance, or AS) and therapeutic interventions.
ABOUT THE AUTHOR
Dr. Jana McHugh is a Clinical Research Fellow in Oncogenetics at The Institute of Cancer Research and Honorary Senior Registrar in Clinical Oncology at the Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom. Dr Jana McHugh undertook her undergraduate medical training in the Royal College of Surgeons in Ireland (RCSI), and completed core medical training and higher specialist training in the Republic of Ireland in Radiation Oncology in 2020. Her current research with Professor Ros Eeles at The Institute of Cancer Research is in prostate cancer and the genetics associated with it. She works with the Oncogenetics team on the role of genetic variation in increased prostate cancer risk.
