William K. Oh, MD, discusses emerging research related to how germline and somatic mutations affect the development and treatment of prostate cancer. He emphasizes the potential for selection of targeted therapies based on genetic testing results.
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Nelson N. Stone, MD, reviews the limitations of systematic biopsy and MRI in regard to accurately localizing and grading of prostate cancer tumors. He describes a 3D transperineal biopsy platform that could improve tumor localization and provide a pathway to targeted focal therapy.
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Nelson N. Stone, MD, identifies high-risk factors for erectile dysfunction and urinary morbidity and discusses management strategies for preventing these complications when treating patients with brachytherapy. He specifically addresses seed implementation techniques in patients with prior prostate surgery and large glands, as well as managing post-implantation symptoms.
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Nelson N. Stone, MD, discusses the need for adequate and accurate prostate cancer identification techniques, especially when selecting patients for active surveillance. He then reviews an emerging transperineal prostate mapping biopsy system that could be an improved tool for fusion biopsy, replace current transrectal biopsy devices, and better detect and localize lesions.
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Nelson N. Stone, MD, discusses long-term data about extended neoadjuvant hormone therapy following radiation therapy for high-risk prostate cancer patients. He observes the morbidity, mortality, and testosterone recovery rates of extended hormone therapy, especially in patients treated with hormone therapy for over 6 months.
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