R. Jonathan Henderson, MD, presented “Challenging Cases in Advanced Prostate Cancer: nmCRPC” during the 30th Annual International Prostate Cancer Update on January 23rd, 2020 in Beaver Creek, Colorado.

How to cite: Henderson, R. Jonathan. “Challenging Cases in Advanced Prostate Cancer: nmCRPC” January 23rd, 2020. Accessed Jul 2024. https://grandroundsinurology.com/challenging-cases-in-advanced-prostate-cancer-nmcrpc/

Challenging Cases in Advanced Prostate Cancer: nmCRPC – Summary:

R. Jonathan Henderson, MD, a urologist with Regional Urology, LLC, discusses an unusual case of non-metastatic castration-resistant prostate cancer (nmCRPC) with a panel featuring Laurence Klotz, MD, FRCSC, Daisaku Hirano, MD, and Michael S. Cookson, MD. The case in question involves an asymptomatic patient in his 70s who was successfully treated for localized prostate cancer and then, ten years later, was treated with cryotherapy for recurrent cancer, after which point cancer stopped appearing in imaging, but the patient’s PSA rapidly rose even as he was treated with abiraterone. Drs. Klotz, Hirano, and Cookson discuss whether it is appropriate to give such treatments to a persistently asymptomatic patient and note that his high PSA could be a response to abiraterone. They also consider the possibility that advanced imaging techniques like PSMA-PET would reveal that the man does have metastases and ponder which of the approved treatments for nmCRPC might suit this patient best.

About The 30th Annual International Prostate Cancer Update:

The International Prostate Cancer Update (IPCU), founded in 1990, is a multi-day CME conference focused on prostate cancer treatment updates with expert, international faculty. It is led by expert physicians and is designed for urologists, medical oncologists, radiation oncologists, and other healthcare professionals involved in the diagnosis and treatment of prostate cancer. Dr. Henderson led this panel discussion during the 30th iteration of the meeting in January 2020.

For further educational activities from this conference, visit our collection page.


R. Jonathan Henderson, MD, is a urologist with Arkansas Urology in Little Rock, Arkansas. He obtained a BS in microbiology from Louisiana State University (LSU) in Baton Rouge. After receiving his MD from LSU Medical Center (LSUMC) in Shreveport, he then completed his internship and residency in urology at LSUMC Hospital. During this time, he also authored a number of papers and presentations.

Dr. Henderson spent the next six years in practice in Alabama, where he specialized in laparoscopy and treating disorders of the female bladder. During this time, he served as a representative of Alabama in the Southeastern Section of the American Urology Association. He also served as an assistant clinical professor of urology at the University of Alabama in Tuscaloosa.

Dr. Henderson focuses his practice primarily on robotic surgeries and the treatment of prostate cancer. He is certified by the American Board of Urology. He is a member of the American Urologic Association, the Shreveport Medical Society, the Louisiana State Medical Society, the Society of Laparoscopic Surgeons, and the Alpha Omega Alpha Medical Honor Society. He is past-president of the Large Urology Group Practice Association (LUGPA) and has served on the Board of Directors since 2011.