Video Archives

Innovations in Bladder Cancer: Strategies for Improving Outcomes Across the Disease Continuum

Posted by Daniel P. Petrylak, MD | Sep 2024

Daniel P. Petrylak, MD, discusses recent advancements in bladder cancer management, highlighting the evolving treatment landscape and the integration of novel therapies. In this 10-minute talk, Petrylak notes a paradigm shift in treating metastatic bladder cancer, moving beyond traditional platinum-based chemotherapies such as gemcitabine and cisplatin, toward immune checkpoint inhibitors.

Petrylak shares trials exploring new therapeutic strategies, such as integrating agents into neoadjuvant and adjuvant settings. For patients ineligible for platinum-based chemotherapy, new protocols involving EV and pembrolizumab provide promising alternatives.

The presentation emphasizes future research’s importance in optimizing treatment sequencing, improving bladder preservation, and minimizing toxicity. With survival rates for metastatic bladder cancer doubling in recent years, ongoing trials are expected to further refine therapeutic strategies and define the next era of bladder cancer care.

Advances in Treating the Primary and Sites of Metastases in Oligometastatic Prostate Cancer

Posted by Jason A. Efstathiou, MD, DPhil | Sep 2024

Jason A. Efstathiou, MD, DPhil, FASTRO, FACRO, highlights the evolving landscape of prostate cancer management, emphasizing the impact of new data, technologies, and clinical trials. A key focus is on the role of radiation therapy in treating metastatic and oligometastatic prostate cancer, particularly in combination with systemic therapies such as androgen deprivation therapy (ADT) and next-generation agents like abiraterone.

In this 11-minute presentation, Dr. Efstathiou reviews studies like the STAMPEDE and the P1 trials, suggesting that radiation combined with intensified systemic therapy can delay disease progression. The presentation also highlights advancements in imaging, such as trials like STOMP and ORIOLE.

Dr. Efstathiou emphasizes the integration of advanced imaging and genomics into clinical practice, allowing better patient selection and risk stratification. The discussion touches on the importance of multidisciplinary care to ensure optimal treatment strategies, particularly as prostate cancer management becomes increasingly complex.

Getting Started with Focal Therapy for Prostate Cancer

Posted by Izak Faiena, MD, MSCR | Sep 2024

Izak Faiena, MD, MSCR, offers a comprehensive overview of focal therapy for prostate cancer, highlighting its role as a targeted, less invasive approach to balance oncologic control with preserving patient quality of life.

In this 10-minute talk, Faiena shows that focal therapy targets the index lesion rather than the entire prostate, maintaining function while controlling cancer. It offers advantages such as fewer side effects, potential for retreatment, and deferral of whole gland therapy.

Several focal therapy modalities are discussed, including cryotherapy, high-intensity focused ultrasound (HIFU), irreversible electroporation (IRE), and focal laser ablation. The presentation underscores the importance of multidisciplinary care, continuous quality improvement, and follow-up.

While focal therapy shows potential, careful patient selection remains critical. The talk concludes with optimism about emerging clinical trials and future developments that may further refine focal therapy’s role in managing prostate cancer.

Update on the State of the Art Radiation Treatments for Prostate Cancer

Posted by Peter F. Orio III, DO, MS | Sep 2024

Peter F. Orio III, DO, MS, discusses radiation oncology for localized prostate cancer. He focuses on a range of advanced techniques aimed at delivering high-dose radiation to the tumor while minimizing toxicity to surrounding tissues. Key modalities include Image-Guided Radiation Therapy (IGRT), Intensity-Modulated Radiation Therapy (IMRT), Stereotactic Body Radiation Therapy (SBRT), and adaptive radiation therapy, each providing distinct advantages in precision and dose management.

Dr. Orio discusses emerging technologies like MR-guided linear accelerators (MR-Linacs), and controversial options like proton therapy and prostate brachytherapy. He also addresses evolving advanced radiation techniques, with artificial intelligence growing in treatment planning and execution.

Despite these advances, ongoing research is necessary to validate the clinical benefits of these technologies and ensure they effectively reduce toxicity and improve patient outcomes. The overarching goal remains to provide personalized, precision radiation therapy that maximizes tumor control while minimizing harm to patients.

Rectal Spacing for All Forms of Radiation: Cryotherapy, HIFU, Tesla, and More

Posted by Peter F. Orio III, DO, MS | Sep 2024

Peter F. Orio III, DO, MS, focuses on the management of localized prostate cancer, particularly emphasizing the use of rectal spacers to reduce radiation toxicity. In this 14-minute presentation, Orio discusses rectal spacing as a pivotal advancement in radiation oncology, enhancing the safety and efficacy of treatments by physically distancing the rectum from the prostate to minimize exposure.

Orio explores various rectal spacing techniques, including SpaceOAR, Barrigel, and BioProtect. The presentation stresses the importance of precise placement and the role of imaging, particularly MRI, in enhancing treatment accuracy and reducing complications. The variability in implant symmetry across products highlights the need to carefully select and use these technologies to avoid adverse effects.

The discussion concludes with considerations for extending the application of these technologies to other modalities, such as cryotherapy and focal laser ablation, reinforcing the broader implications of tumor spacing in oncologic treatment.