Video

Standardized MRI and Molecular Imaging Reporting for Focal Therapy Follow-up – Creating Imaging Based Short and Intermediate Outcomes

Daniel Margolis, MD, focuses on standardized MRI and molecular imaging reporting for follow-up in prostate cancer focal therapy. Implementing standardized protocols for imaging evaluation post-focal therapy aims to ensure consistency and reliability across different healthcare settings, facilitate accurate comparison of treatment outcomes, and enable evidence-based decision-making.
Multiparametric MRI (mpMRI) is a cornerstone of the follow-up strategy. By utilizing standardized reporting systems such as the Prostate Imaging Reporting and Data System (PI-RADS), radiologists can systematically assess post-treatment changes, detect residual or recurrent disease, and monitor treatment response. Dr. Margolis also discusses molecular imaging techniques that offer additional insights into treatment response and disease activity at a molecular level. Novel tracers and imaging agents target specific biological markers associated with prostate cancer, enhancing the precision and sensitivity of post-treatment assessments.
Dr. Margolis emphasizes the importance of integrating these imaging modalities into a cohesive framework. This approach not only aids in the early detection of treatment failure or disease recurrence but also guides timely intervention and adjustment of therapeutic strategies.

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Choosing Systemic Therapy for Men with Metastatic Hormone Sensitive Prostate Cancer

Andrew W. Hahn, MD, analyzes systemic therapy choices for men with metastatic hormone-sensitive prostate cancer. His presentation delves into the critical factors influencing treatment decisions and the latest advancements in therapeutic options.
Dr. Hahn begins by outlining current systemic therapies, including androgen deprivation therapy (ADT) and its combination with other agents. By discussing the mechanisms of action and the efficacy of various therapeutic agents, Dr. Hahn provides a detailed examination of the available treatment options.
Dr. Hahn also addresses the role of personalized medicine in managing metastatic hormone-sensitive prostate cancer. He highlights the importance of genetic profiling and biomarker testing in tailoring treatment plans to individual patients.
Throughout the presentation, Dr. Hahn underscores the dynamic nature of prostate cancer treatment, with ongoing research continually informing and refining clinical practice.

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Implementing Changes in Patient Behavior

Jason M. Hafron, MD, provides guidance on implementing changes in ADT patient behavior and motivating compliance with lifestyle adjustments. He begins by reviewing the body composition changes which result from ADT.

Dr. Hafron discusses how these changes in body composition, along with other adverse effects of ADT, led to the creation of the Prostate Cancer 360 (PC36) Working Group. This interdisciplinary group developed monitoring and management recommendations intended to mitigate or prevent ADT-associated adverse events in a PC360 Handbook, which includes pre-ADT counseling on lifestyle changes.

He presents the benefits of different levels of physical exercise for patients on ADT. He examines data demonstrating the impact of standardized exercise on ADT patient QoL, noting that physical exercise has significant benefits.

Dr. Hafron concludes with guidance on patient nutrition. He notes that diet has a significant influence on prostate cancer survival rate, with a typical Western diet significantly increasing the mortality rate for patients on ADT.

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