Latest Videos

Point-Counterpoint: There is a Role for Currently Available Biomarkers/Genomics in the Risk Stratification of Prostate Cancer

E. David Crawford, MD, Editor-in-Chief of Grand Rounds in Urology, and Alan H. Bryce, MD, Chair of the Division of Hematology and Medical Oncology and Assistant Professor of Medicine at the Mayo Clinic in Phoenix, Arizona, present a Point-Counterpoint on the relative value of genomics and biomarkers in prostate cancer risk stratification. Dr. Crawford, presenting the pro side, argues that doctors need to do biomarker testing to know which patients to biopsy, follow closely, and treat with radiation. Dr. Bryce, presenting the con side, contends that while germline testing is beneficial, other biomarker tests have inconsistent results for prostate cancer patients.

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Prostate Imaging and Biopsy Controversies

Neal D. Shore, MD, FACS, Medical Director for the Carolina Urologic Research Center, discusses the evolution of transrectal (TR) versus transperineal (TP) prostate biopsy, and compares the efficacy of multi-parametric MRI (mpMRI) versus next generation micro-ultrasound. He goes on to discuss several studies that review the complication rates of TR and TP biopsy, differences in their diagnostic sensitivity, and various procedural techniques associated with TP prostate biopsy. Dr. Shore then examines several landmark studies that summarize the clinical utility of mpMRI and micro-ultrasound and describes the strengths and weaknesses associated with each technique. He concludes by discussing preliminary data comparing the diagnostic performance of micro-ultrasound to mpMRI.

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New Concepts in Cavernous Nerve Localization and Functional Recovery after Radical Prostatectomy

Arthur L. Burnett II, MD, MBA, FACS, Professor of Urology at Johns Hopkins University School of Medicine, discusses therapeutic and investigational strategies for improving erectile function after prostatectomy. He goes on to discuss how cavernous nerve-sparing techniques have reduced erectile dysfunction after prostatectomy by 10-40%, how mapping cavernous nerves with novel imaging techniques can help minimize nerve and vascular injury at the time of surgery, as well as the impact of investigational, local electrostimulation of damaged cavernous nerves in an animal model cohort.

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Cesium-131 Prostate Brachytherapy: A Single Institutional Long-Term Experience

Ronald M. Benoit Jr., MD, Associate Professor, Clinical Vice Chair of Urology, Director of General Urology, and Chief of the Division of Community Urology at the University of Pittsburgh School of Medicine, describes the long-term results of a single institution cohort study investigating brachytherapy using Cesium-131 (Cs-131) in 669 prostate cancer patients. He goes on to describe the long-term impact on urinary function caused by using iodine and palladium implants, how study results using Cs-131 demonstrated shorter duration of urinary morbidity, and the relative 5- and 10-year biochemical-free recurrence rate among patients stratified at low, intermediate, and high risk levels.

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