Alan H. Bryce, MD

Alan H. Bryce, MD

Mayo Clinic

Phoenix, Arizona

Dr. Bryce studies cancer genetics and novel therapeutics with a focus on personalized medicine. His clinical practice focuses on genitourinary malignancies (prostate, kidney, bladder, and testicular cancers) and melanoma. He is Chair of the Division of Hematology and Medical Oncology and Assistant Professor of Medicine at Mayo Clinic in Phoenix, Arizona. He is also the Medical Director of the Genomic Oncology Clinic at Mayo Clinic Arizona, where he utilizes whole genome sequencing of tumors to identify key driver mutations. This approach allows for precise targeting of a patient’s tumor, leading to a greater chance of remission. Dr. Bryce participates in community outreach to underserved populations and has in interest in health disparities research. He also conducts Phase I clinical trials of new cancer drugs.

Articles by Alan H. Bryce, MD

Adjuvant Therapy in High Risk Renal Cell Carcinoma

Alan H. Bryce, MD, surveys data from three phase III trials on adjuvant therapies for high-risk renal cell carcinoma. He discusses the controversies following the conclusions of the completed trials and emphasizes the need for research in further adjuvant therapies beyond those that target the VEGF pathway.

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Genetic Testing and Next Generation DNA Sequencing

Alan H. Bryce, MD, explains the concept of synthetic lethality in the context of BRCA-deficient tumors, as well as resistance to poly (ADP-ribose) polymerase (PARP) inhibition. He also discusses the under-utilization of inherited cancer risk syndromes in prostate cancer practice, research, and guidelines, as well as new pathways for therapeutic targeting

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