Perspectives in Urology: Point-Counterpoint

Can the DECIPHER Marker Predict Chemotherapy?

Robert Abouassaly, MD, argues that the DECIPHER marker is not an ideal test for predicting patient’s response to chemotherapy. He cites the inconclusiveness of trials and research and the cost inefficiency of this biomarker. Also, he explains that the DECIPHER test’s classification system is based on RNA expression profiles, and not meant for therapeutic guidance. This is a counter argument to Alan H. Bryce’s lecture, “The DECIPHER Marker Can Predict Chemotherapy.” 

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The DECIPHER Marker Can Predict Chemotherapy

Alan H. Bryce, MD makes the pro side of the argument that the DECIPHER marker is an effective tool for predicting a patient’s response to chemotherapy. He also summarizes the ongoing trials and research regarding this specific biomarker. This is a counter argument to Robert Abouassaly’s lecture, “Can The DECIPHER Marker Can Predict Chemotherapy?”

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BCG Failure: BCG Maintenance Should be Less Intense

Dr. Erik P. Castle, MD, explains the Southwest Oncology Group’s (SWOG’s) protocol for administering maintenance doses of bacillus Calmette-Guerin (BCG) to non-muscle invasive bladder cancer patients. He argues that carrying out the full SWOG course makes a positive impact on patients’ recurrence free survival rates, identifying the ideal disease types and patients to receive the full course.

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BCG Maintenance – Full SWOG Course – Pro Argument

Erik P. Castle, MD, explains the Southwest Oncology Group’s (SWOG’s) protocol for administering maintenance doses of bacillus Calmette-Guerin (BCG) to non-muscle invasive bladder cancer patients. He argues that carrying out the full SWOG course makes a positive impact on patients’ recurrence free survival rates, identifying the ideal disease types and patients to receive the full course.

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