Jennifer M. Taylor, MD, MPH, discusses the factors that led to the current opioid epidemic and the consequences of excessive perioperative opioid prescribing. She then identifies concrete and evidence-based strategies to reduce opioid prescribing and use in particular surgical cases.
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A. Edward Yen, MD, discusses the incidence, prognosis, and therapeutic considerations for regionally advanced prostate cancer. He defines the delineation between clinical and pathologic lymph node metastatic prostate cancers and emphasizes the importance of prescribing therapy based on individual risk factors.
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Dov Kadmon, MD, defines locally advanced prostate cancer and the basic principles of managing this group of patients on the basis of multiple urologic and oncologic societies’ guidelines. He discusses the current standard of care, as well as ongoing research into the addition of systemic therapies for these patients.
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Michael J. Zelefsky, MD, argues that combining stereotactic body radiation therapy (SBRT) with low-dose rate brachytherapy can help to reduce the morbidities of combined-modality radiotherapy. He also emphasizes the need to address the issue of toxicity with careful patient selection, treatment planning, and adherence to tight dose constraints.
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Nelson N. Stone, MD, explains that many studies show benefits from combination external beam radiation therapy (EBRT) and brachytherapy in high-risk prostate cancer patients. He then discusses potential reasons for these benefits and the impact of brachytherapy dosage in patient outcomes.
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