Permanent Prostate Brachytherapy – Brian J. Moran Distinguished Lecture

Brian J. Davis, MD, PhD, presented “Permanent Prostate Brachytherapy – Brian J. Moran Distinguished Lecture” during the 35th International Prostate Cancer Update conference on February 11, 2025, in Vail, Colorado.

How to cite: Davis, Brian J. “Permanent Prostate Brachytherapy – Brian J. Moran Distinguished Lecture.” February 11, 2025. Accessed Apr 2025. https://grandroundsinurology.com/permanent-prostate-brachytherapy-brian-j-moran-distinguished-lecture/

Permanent Prostate Brachytherapy – Brian J. Moran Distinguished Lecture
– Summary

The 2025 International Prostate Cancer Update honors the legacy of Brian J. Moran, a leader in radiation oncology and a pioneer in prostate brachytherapy. His contributions to prostate cancer treatment, particularly in permanent brachytherapy, have shaped the field and improved patient outcomes. Introduced by Peter Orio III, DO, MS, Brian J. Davis, MD, PhD, Mayo Clinic, Rochester, Minnesota, delivers the presentation.

In this 30-minute presentation, Dr. Davis revisits the ongoing debate between focal and whole-gland brachytherapy for prostate cancer. He emphasizes the limitations of focal therapy, citing that prostate cancer is often multifocal and imaging may fail to detect all malignancies. Whole-gland treatment remains the standard due to its superior long-term outcomes.

Dr. Davis transitions to an exploration of PSMA PET imaging in recurrent prostate cancer, sharing that salvage nodal radiation combined with androgen deprivation therapy (ADT) has shown promising results in controlling recurrent disease. Data from Mayo Clinic and European studies confirm that comprehensive nodal irradiation is superior to SBRT alone in preventing further progression.

Dr. Davis references a clinical trial investigating moderate hypofractionation for salvage nodal radiation. This approach, combined with IMRT or proton therapy, minimizes gastrointestinal toxicity and enhances patient outcomes. The trial’s results reinforce the importance of comprehensive nodal irradiation rather than targeted SBRT in managing recurrence.

The talk concludes with a tribute to Moran’s legacy, acknowledging his influence on modern radiation oncology. His dedication to mentorship, innovation, and patient care remains a guiding force in the field. Through the Moran Lectureship Award, his name and work will be remembered for generations, inspiring ongoing advancements in prostate cancer research and treatment.

About the 35th International Prostate Cancer Update:

The International Prostate Cancer Update (IPCU), is a multi-day, CME-accredited conference focused on new developments in prostate cancer treatment, diagnosis, and prevention. IPCU 35 will feature lectures, interactive discussions, panel roundtables, debates, and case reports. This conference is led by expert physicians and is designed for urologists, medical oncologists, radiation oncologists, and other healthcare professionals involved in the diagnosis and treatment of prostate cancer.

The goal of this educational program is to equip healthcare professionals involved in the diagnosis and treatment of prostate cancer with the up-to-date clinical knowledge and tools they need to best treat their patients. The program will discuss the treatment of prostate cancer from diagnosis to treating advanced and metastatic disease. The conference aims to give physicians exposure to a comprehensive review of treating prostate cancer patients and to give them a chance to discuss the issues with peers and experts. You can learn more about the conference here.