Alan H. Bryce, MD, presented “Putting Germline Testing into Context – A Primer and Current Knowledge” during the 34th International Prostate Cancer Update on February 12, 2024, in Vail, Colorado.
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How to cite: Bryce, Alan H. “Putting Germline Testing into Context – A Primer and Current Knowledge.” February 2024. Accessed Dec 2024. https://grandroundsinurology.com/putting-germline-testing-into-context-a-primer-and-current-knowledge/
Putting Germline Testing into Context – A Primer and Current Knowledge – Summary
Alan H. Bryce, MD, outlines the current state and potential future directions of germline testing in prostate cancer detection and treatment. He begins with a review of the currently known genetic mutations associated with prostate cancer.
Dr. Bryce then reviews the NCCN criteria for germline genetic testing for patients with new or previously diagnosed prostate cancer. He presents data that supports the idea that current testing guidelines are not effective in identifying the presence of known pathogenic germline variants (PVGs) in patients with prostate cancer.
Dr. Bryce then examines the relationship between disease progression and the presence of PVGs. He presents data illustrating the correlation of certain PVGs and the likelihood of disease progression.
Dr. Bryce concludes by highlighting the lack of available data for different racial groups. He notes that most of the available PGV data is based on the testing and surveillance of Caucasian males, leaving all other racial groups underrepresented in the data.
About The 34th Annual International Prostate Cancer Update:
The International Prostate Cancer Update (IPCU), founded in 1990, is a multi-day CME conference focused on prostate cancer treatment updates with expert, international faculty. It is led by expert physicians and is designed for urologists, medical oncologists, radiation oncologists, and other healthcare professionals involved in the diagnosis and treatment of prostate cancer. The 34th iteration of the meeting occurred February 11-14, 2024 in Vail, Colorado. To view more educational presentations from IPCU 34, visit our collection page.
