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ERA 223 Study | Concerns About Using Radium-223 and Abiraterone

by E. David Crawford, MD | Dec 2017

The IDMC’s Recommendation to Unblind a Phase III Trial of Radium-223 in Combination with Abiraterone Acetate for Prostate Cancer

Breaking News about the ERA 223 Trial, a phase III trial of radium-223 in combination with abiraterone acetate and prednisone/prednisolone for patients with metastatic castration-resistant prostate cancer unblinded:

In early December 2017, the ERA 223 trial released safety concerns of the combination arm of abiraterone acetate and radium-223 of prostate cancer patients. The information released suggests that patients receiving radium-223 with abiraterone acetate had more incidences of bone fractures and deaths.

About The Author

E. David Crawford, MD

E. David Crawford, MD, is a Professor of Urology at the University of California, San Diego. He is an internationally renowned urologist, and the former distinguished endowed Professor of Surgery, Urology, and Radiation Oncology, and Head of the Section of Urologic Oncology at the University of Colorado Anschutz Medical Campus in Aurora, Colorado. Dr. Crawford is an expert in benign prostate hypertrophy, urologic cancers, and in particular, prostate cancer. He has authored many scientific articles, as well as textbooks and book chapters. He has served as an editorial reviewer or consultant for many publications, including Urology, Journal of Urology, and the Journal of Clinical Oncology. Dr. Crawford is a member of many organizations, including the American Society of Clinical Oncology (ASCO), the American Urological Association (AUA), and the American Association for the Advancement of Science (AAAS). He is the Founder and Chairman of the Prostate Conditions Education Council, which is responsible for raising awareness and screening of millions of men for prostate health issues. He has received many awards, including the CaP CURE Annual Award for Scientific Presentation, and has twice been presented with a “Freddie Award” for best medical documentaries. He has long been recognized as one of the Best Doctors of America and is recognized as one of the top 20 urologists in the country for men by Men’s Health Magazine.

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