Manoj Monga, MD, and Aaron W. Miller, PhD, presented “The Implications of the Microbiome on Stone Pathophysiology, Stone Prevention and Novel Diagnostics” for the Grand Rounds in Urology audience in January, 2020.
How to cite: Miller, Aaron W. “The Implications of the Microbiome on Stone Pathophysiology, Stone Prevention and Novel Diagnostics” January, 2020. Accessed Dec 2024. https://grandroundsinurology.com/the-implications-of-the-microbiome-on-stone-pathophysiology-stone-prevention-and-novel-diagnostics/
The Implications of the Microbiome on Stone Pathophysiology, Stone Prevention and Novel Diagnostics – Summary:
Manoj Monga, MD, and Aaron W. Miller, PhD, discuss the effect of the microbiome of the gut and urinary tract on the development and prevention of stone disease. Dr. Miller discusses research into oxalate metabolism in the gut that can lead to kidney stones, how the bacteria lactobacillus crispatus may reveal clues about metabolites that can help prevent the incidence of stones, as well as a strain of E. coli that may be connected to their increase.
ABOUT THE AUTHOR
Aaron W. Miller, PhD, is a functional microbial ecologist and Head of the Stones Translational Research Laboratory at the Cleveland Clinic. The focus of his research is primarily in how the microbiome promotes or inhibits disease processes, particularly for urinary stone disease. His work involves the use of multi-omics experiments in the laboratory and in the clinic to establish connections among the host, microbe, and metabolism. The goal of this research is to develop novel diagnostic and therapeutic options to better identify individuals at risk for recurrent urinary stone disease and treat them through targeted bacteriotherapies designed to restore vital microbial functions that prevent the onset of the disease.
