Paul Boutros, PhD, MBA, presented “The Prostate Cancer Proteome” during the 7th Global Summit on Precision Diagnosis and Treatment of Prostate Cancer on September 21, 2023.
How to cite: Boutros, Paul. “The Prostate Cancer Proteome.” September 21, 2023. Accessed Nov 2025. https://grandroundsinurology.com/the-prostate-cancer-proteome/
The Prostate Cancer Proteome – Summary
Paul Boutros, PhD, MBA, gives a talk on the under-explored prostate cancer proteome. Dr. Boutros discusses proteomics by delving into five reasons why they are a useful tool. His talk focuses on these reasons and he goes into detail about each one. They include the fact that proteins are the actual function units of the central dogma, they are far more diverse than RNA, they have not been looked at in much detail yet, they are abundant in urine and they have immense dynamic range. His talk then goes on to cover what tissue proteomics look like, how the proteome relates to other things we care about such as MRI visibility and urinary proteomics. He ends the talk by going over some of the caveats and reasons that proteomics might not work. Overall proteomics are incredibly complex and few have the skills to properly analyze, but it remains a major opportunity to move forward in the field.
The Global Summit on Precision Diagnosis and Treatment of Prostate Cancer is a unique multi-disciplinary forum organized to inform the key health care stakeholders about the emerging advances in clinical case and research and create a consensus-based vision for the future of precision care and educational and research strategy for its realization. The mission of the Summit is to fill the currently existing gap between the key experts of in vivo imaging, the world authorities in the in vitro fluid- and tissue-based molecular diagnostics, including genomics, and thought leaders in the development of novel observation strategies (e.g., active surveillance, or AS) and therapeutic interventions.
ABOUT THE AUTHOR
Paul C. Boutros, PhD, MBA, is the Interim Vice Dean of Research and a Professor in the Human Genetics and Urology departments at the University of California, Los Angeles. Dr. Boutros’ research lies at the intersection of clinical, molecular and imaging data. He focuses on how these diverse pieces of information can be linked to personalize therapy for cancer patients. His work sometimes centers on specific tumor types, particularly prostate and thyroid, but often includes others in conjunction to identify general and tumor-type specific features of cancer. Some of his recent studies focus on how cancers develop differently based on the sex, age, or ethnic features of the patient.
