R. Jonathan Henderson, MD

Arkansas Urology

Little Rock, Arkansas

R. Jonathan Henderson, MD, is a urologist with Arkansas Urology in Little Rock, Arkansas. He obtained a BS in microbiology from Louisiana State University (LSU) in Baton Rouge. After receiving his MD from LSU Medical Center (LSUMC) in Shreveport, he then completed his internship and residency in urology at LSUMC Hospital. During this time, he also authored a number of papers and presentations.

Dr. Henderson spent the next six years in practice in Alabama, where he specialized in laparoscopy and treating disorders of the female bladder. During this time, he served as a representative of Alabama in the Southeastern Section of the American Urology Association. He also served as an assistant clinical professor of urology at the University of Alabama in Tuscaloosa.

Dr. Henderson focuses his practice primarily on robotic surgeries and the treatment of prostate cancer. He is certified by the American Board of Urology. He is a member of the American Urologic Association, the Shreveport Medical Society, the Louisiana State Medical Society, the Society of Laparoscopic Surgeons, and the Alpha Omega Alpha Medical Honor Society. He is past-president of the Large Urology Group Practice Association (LUGPA) and has served on the Board of Directors since 2011.

Talks by R. Jonathan Henderson, MD

Challenging Cases in Advanced Prostate Cancer: nmCRPC

R. Jonathan Henderson, MD | Jun 2020

R. Jonathan Henderson, MD, a urologist with Regional Urology, LLC, discusses an unusual case of non-metastatic castration-resistant prostate cancer (nmCRPC) with a panel featuring Laurence Klotz, MD, FRCSC, Daisaku Hirano, MD, and Michael S. Cookson, MD. The case in question involves an asymptomatic patient in his 70s who was successfully treated for localized prostate cancer and then, ten years later, was treated with cryotherapy for recurrent cancer, after which point cancer stopped appearing in imaging, but the patient’s PSA rapidly rose even as he was treated with abiraterone. Drs. Klotz, Hirano, and Cookson discuss whether it is appropriate to give such treatments to a persistently asymptomatic patient and note that his high PSA could be a response to abiraterone. They also consider the possibility that advanced imaging techniques like PSMA-PET would reveal that the man does have metastases and ponder which of the approved treatments for nmCRPC might suit this patient best.

Androgen Annihilation as a New Therapeutic Paradigm in Advanced Prostate Cancer

R. Jonathan Henderson, MD | May 2019

R. Jonathan Henderson, MD, argues that the goal of ADT should be to achieve and maintain the lowest levels of T possible in prostate cancer patients. The FDA-recommended target low of 50 ng/dL originates from constraints of outdated technology, and multiple studies indicate that there is a benefit to patients when T-levels fall below 20 ng/dL.

The LUGPA Alternative Payment Model (APM) on Newly Diagnosed PCa and the Role of Active Surveillance

R. Jonathan Henderson, MD | Apr 2018

R. Jonathan Henderson, MD, summarizes the Large Urology Group Practice Association’s (LUGPA’s) efforts to develop an alternative payment model (APM) for urologists treating newly diagnosed prostate cancer patients. He explains the roadblocks to reaching this goal, including conflicts with the Physician-Focused Payment Model Technical Advisory Committee (PTAC).