William K. Oh, MD, discusses emerging research related to how germline and somatic mutations affect the development and treatment of prostate cancer. He emphasizes the potential for selection of targeted therapies based on genetic testing results.
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Nelson N. Stone, MD, reviews the limitations of systematic biopsy and MRI in regard to accurately localizing and grading of prostate cancer tumors. He describes a 3D transperineal biopsy platform that could improve tumor localization and provide a pathway to targeted focal therapy.
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M. Scott Lucia, MD, reviews the historical utilization of the Gleason grading score as an indicator of prostate cancer prognosis and the refinements the system has undergone to improve predictive accuracy. He examines changes to the grading of cribriform carcinoma, as well as an improved 5-tier grade classification system.
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Leonard S. Marks, MD, reviews the utility of MR/US fusion prostate biopsy devices in detecting clinically significant prostate cancer and guiding targeted focal therapy. He also discusses how to develop a MR/US fusion biopsy procedure and integrate its use into a clinical practice.
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Jason A. Efstathiou, MD, DPhil, reviews the results of randomized studies and large retrospective experiences evaluating the efficacy, safety, and timing of post-prostatectomy radiation. He discusses the role of androgen deprivation therapy in addition to radiation in the salvage postoperative setting, and the potential use of genomic and advanced imaging biomarkers in patient treatment selection.
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