Michael J. Zelefsky, MD, discusses the use of post-radiotherapy prostate biopsy to assess local tumor control following radiotherapy. He argues that post-treatment biopsy can benefit patients by allowing for earlier identification of local recurrences and initiation of salvage therapy than would be possible when relying upon PSA and multiparametric MRI.
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Nelson N. Stone, MD, identifies high-risk factors for erectile dysfunction and urinary morbidity and discusses management strategies for preventing these complications when treating patients with brachytherapy. He specifically addresses seed implementation techniques in patients with prior prostate surgery and large glands, as well as managing post-implantation symptoms.
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Abraham Morgentaler, MD, explains new concepts that could subvert the long-held belief that high levels of testosterone exacerbate prostate cancer growth. He discusses the androgen saturation model, as well as the benefits of testosterone therapy for patients’ quality of life.
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Nelson N. Stone, MD, discusses long-term data about extended neoadjuvant hormone therapy following radiation therapy for high-risk prostate cancer patients. He observes the morbidity, mortality, and testosterone recovery rates of extended hormone therapy, especially in patients treated with hormone therapy for over 6 months.
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Mohit Khera, MD, MBA, MPH, reviews the literature surrounding the safety of testosterone replacement therapy (TRT) following prostate cancer treatment, including after brachytherapy, EBRT, and radical prostatectomy (RP). He also discusses the concept of bipolar androgen therapy (BAT) and the importance of TRT for erectile preservation post-RP.
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