Video

Sphincter-Saving Technique in HoLEP Surgery

As part of Grand Rounds in Urology’s ongoing series highlighting urologists working in Asia, Seung-June Oh, MD, PhD, Professor of Urology at Seoul National University in Seoul, South Korea, explains and demonstrates his sphincter-saving technique for holmium laser enucleation of the prostate (HoLEP) surgery. After an introduction by Peter K.F. Chiu, MD, PhD, FRCSEd, Dr. Oh goes over the benefits and difficulties of HoLEP for benign prostatic hyperplasia, emphasizing the problems of post-operative urinary incontinence. He then goes over strategies for maximally preserving the continence mechanism during HoLEP and introduces his Early Inverted V-shaped Apical Mucosal (EVAMI) Technique before showing footage of a routine HoLEP surgery. The presentation concludes with a question and answer session led by Dr. Chiu.

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Urine Biomarkers for the Detection of Urothelial Carcinoma

Siamak Daneshmand, MD, Associate Professor of Urology and Director of Clinical Research at the University of Southern California discusses the ability of urinary markers to rule out bladder cancer and decrease the frequency of and need for cystoscopy and cytology. He goes over the limitations and adverse effects of cystoscopy and cytology before summarizing the findings of several studies looking at different urinary biomarkers for bladder cancer, including Cxbladder, Bladder EpiCheck, Bladder CARE™, and Decipher Bladder.

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The Science of Testosterone and Atherosclerosis

Daniel Kelly, PhD, Senior Lecturer of Biochemistry at Sheffield Hallam University and University of Sheffield reviews data on testosterone’s complex impact on atherosclerosis. He outlines the key stages of atherosclerosis: monocyte activation, monocyte activation/adhesion, monocyte migration, and macrophage activation, and discusses how testosterone impacts each stage with supporting studies.

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MRI-US Fusion Target Management of Prostate Cancer in the Office Setting

Fernando J. Bianco, MD, Investigator-in-Chief for the Urological Research Network in Miami, Florida, discusses treatment of prostate cancer using MRI-ultrasound fusion biopsy in an office setting. Dr. Bianco remarks how the results of the PIVOT and ProtecT trials have shifted the emphasis away from radical prostatectomy to focal therapy. The next consideration has been whether the procedure could be done in an office setting if sedation or anesthesia were not needed. The development of a transperineal block allowed physicians to perform biopsy and treatment in-office under local anesthesia. Dr. Bianco then describes his technology, Focalyx® Fusion, which uses MRI-ultrasound fusion to diagnose, biopsy, and then treat using cryoablation. The combination of MRI and ultrasound fusion during treatment provide the physician with a clearer picture of the treatment in real-time. The technology utilizes programmed workflows to prioritize patients and also shares procedure results back to the patients via an app. He notes that patients show a drop in PSA, improved urinary function, and no major deterioration in rectal performance following the procedure. Dr. Bianco also discusses current research to determine whether prophylactic antibiotics before a transperineal prostate biopsy are necessary.

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