Marc B. Garnick, MD, discusses whether or not follicle stimulating hormone (FSH) affects prostate cancer progression and cause adverse effects when used in combination with androgen deprivation therapy (ADT). He presents evidence for both the pro and con sides of this argument.
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Dr. Gerald L. Andriole, MD, reviews the designs, materials, and outcomes of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO) and The European Randomized Study of Screening for Prostate Cancer (ERSPC). He distinguishes between legitimate concerns and inappropriate criticisms of the trials. Also, he explains what this means for the practice of PSA testing.
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Dr. Neal Shore, MD, FACS, stands in for Deepak A. Kapoor, MD, at the 28th International Prostate Cancer Update, summarizing the history of the United States Preventive Services Task Force (USPSTF) and their Recommendation Grades for disease prevention and screening services. He explains the issues that arise when lawmakers attempt to use USPSTF recommendations as a basis for insurance laws. Specifically, he explains how healthcare policy effects PSA testing.
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Daniel P. Petrylak, MD, discusses the efficacy of checkpoint inhibitors in previously cisplatin treated metastatic urothelial carcinoma patients and the need for better biomarkers for checkpoint proteins. He also identifies future directions for treating the disease, including ipilimumab/nivolumab and epacadostat/ pembrolizumab combinations, and PD-L1 immunohistochemical staining.
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Peter Black, MD, FRCSC, fills in for Ashish Kamat, MD, at the 2nd annual IBCU, discussing why and how clinicians should adapt bladder cancer treatment based on variant histologies. Dr. Black identifies sub-types of bladder cancer and the way gene expression and squamous differentiation play a role in risk-stratifying the disease. He explains the proper management of each sub-type, including MD Anderson treatment algorithms for NMIBC and MIBC.
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