John P. Mulhall, MD, presented “Testosterone Recovery Profiles After Cessation of Androgen Deprivation Therapy” during the 39th Annual Ralph E. Hopkins Urology Seminar on January 30th, 2019 in Jackson Hole, Wyoming.

How to cite: Mulhall, John P. “Testosterone Recovery Profiles After Cessation of Androgen Deprivation Therapy” January 30th, 2019. Accessed Apr 2024.

Testosterone Recovery Profiles After Cessation of Androgen Deprivation Therapy – Summary:

John P. Mulhall, MD, discusses the significant sexual and non-sexual adverse events of low testosterone resulting from using androgen deprivation therapy (ADT) to treat men with prostate cancer. He emphasizes the need for physicians to counsel patients on long-term expectations and to obtain fully-informed consent prior to the initiation of this therapy. 


The utilization of ADT for the treatment of prostate cancer is increasingly common, and its role in metastatic disease—in conjunction with radiation therapy—in the neoadjuvant pre-radical prostatectomy setting is constantly evolving. 

Unfortunately, there are significant sexual and non-sexual consequences that result from depleted or very low testosterone in men. Historically, ADT has negatively impacted erectile function.

Furthermore, free testosterone levels correlate with orgasm function. In an evaluation of orgasm profiles in patients receiving ADT, the mean time to complete loss of orgasm was 5 months on therapy, and all patients had a significant reduction in orgasm intensity. The non-sexual sequelae of ADT include the reduction of insulin sensitivity, an increased risk of diabetes, cardiovascular events, bone density loss, and increased mortality.  

Despite the fact that incomplete testosterone recovery is common after cessation of ADT, an alarming number of men treated with ADT, as well as their partners, lack an awareness of its negative effects. For these reasons, it is essential that physicians assess baseline total testosterone levels in men and counsel patients about long-term expectations prior to the initiation of ADT

About the Ralph E. Hopkins Urology Seminar

The Ralph E. Hopkins Urology Seminar, or Jackson Hole Seminars (JHS), is a multi-day conference that focuses on patient safety and cutting-edge updates in the assessment, diagnosis, and treatment of urologic conditions. The topics discussed include urologic cancers, stone disease, urologic reconstruction, female urology, infertility, emerging surgical techniques, and general urology. In addition to didactic expert lectures, this conference features a unique interactive critique panel. Dr. Mulhall presented this lecture during the 39th Annual JHS. Please visit this page in order to register for future JHS meetings.