Latest Videos Archives

Androgen Deprivation Therapy: A Closer Review of the Role of Anti-Androgens

Posted by Thomas E. Keane, MD | May 2020

Thomas E. Keane, MD, Professor and Chairman of the Department of Urology at the Medical University of South Carolina in Charleston, discusses the role of anti-androgens in androgen deprivation therapy (ADT). Dr. Keane looks at some studies out of Canada showing the ideal T levels during ADT, but goes on to point out that both the FDA and EU regulatory authorities do not follow these guidelines. He emphasizes throughout his talk why this is problematic and why doctors should be following the Canadian guidelines. He also goes over some of the adverse effects of ADT and emphasizes the increased risk for cardiovascular and liver disease. Dr. Keane goes on to discuss different clinical data that show how to address these risks.

What Role Do Markers Play in Establishing Active Surveillance or Definitive Care?

Posted by Gerald L. Andriole, Jr., MD | May 2020

Gerald L. Andriole, Jr., MD, explains that while active surveillance is on the rise, doctors can do a better job of selecting patients for it. He points out that NCCN and ASCO guidelines indicate that routine ordering of molecular biomarker tests is not recommended, and state that doctors should only perform active surveillance on low- and favorable-risk patients. He concludes that clinical criteria are very useful in determining when to use active surveillance, and notes that MRI and gene expression classifiers add some certainty to the decision. There are other markers that may aid in decision making, but the current data is sparse.

Diet, Exercise + Prostate Cancer

Posted by David Utz | May 2020

Diet, Exercise + Prostate Cancer This interview, “Diet, Exercise + Prostate Cancer,”...

Are MRI Fusion Biopsies Necessary for Urologists?

Posted by Jelle Barentsz, MD, PhD | May 2020

E. David Crawford, MD, Editor-in-Chief of Grand Rounds in Urology, interviews Jelle Barentsz, MD, PhD, Professor of Radiology at the University in Nijmegen in the Netherlands, about prostate cancer suspicions and which metrics define prostate cancer risk. Dr. Barentsz discusses the steps that must be taken if there is a suspicion of prostate cancer and emphasizes the importance that MRIs and molecular markers play in this. He notes that in an optimal world with a perfect MRI a molecular marker test is often unnecessary, but that sometimes we do not have perfect MRIs, and in these cases, molecular marker tests like SelectMDX are good tests to use. However, MRIs offer more information about potential cancer and are also better at excluding more significant cancers than molecular marker tests. Dr. Crawford and Dr. Barentsz come to the conclusion that which is better or necessary often depends on the country the patient resides in.

Challenging Cases in Advanced Prostate Cancer- mHSPC

Posted by E. David Crawford, MD | May 2020

E. David Crawford, MD, Editor-in-Chief of Grand Rounds in Urology and Professor of Urology at University of California, San Diego, gives his expertise on next generation biomarkers in prostate cancer screening. Firstly, Dr. Crawford qualifies the new standard of PSA >1.5 ng/mL, specifically how it aids in early detection of disease and acts as a surrogate for BPH, prostate cancer, and prostatitis. Following this, Dr. Crawford reviews the clinical needs and genomic markers of prostate cancer. In conclusion, he describes his algorithm for PSA screening.