Thomas E. Keane, MD

Thomas E. Keane, MD

Medical University of South Carolina

Charleston, SC

In June 2002, Dr. Thomas Keane, a surgical urologic oncologist and nationally recognized researcher with previous appointments at Emory University and Grady Memorial Hospital in Atlanta, accepted the position of Chairman of Urology at MUSC. Dr. Keane obtained his medical degree in Ireland and completed 7 years of general surgery before obtaining a research fellowship at Duke University which led to a urologic residency.
He is currently a Professor of Urology and holds the Brockmann Chair in Urologic Oncology. An avid researcher, he has served as principal investigator/co-investigator on more than 20 major clinical/pre-clinical studies. His work focuses on innovative concepts in translational research, including utilizing human tumor xenografts to investigate new therapies as they relate to GU malignancies with particular reference to cytotoxic agents, sphingolipids, and boron-containing compounds. He holds a number of U.S. patents.

Dr. Keane has published over 100 articles peer-reviewed in such journals as The Journal of Urology, Journal of Clinical Investigation, and Cancer Research. He provides editorial services to numerous urology journals and is coeditor of the text Glenn’s Urologic Surgery. Dr. Keane has chaired the renal section of the Eastern Cooperative Oncology Group and is an accomplished speaker, having delivered many presentations to professional societies and symposia throughout the United States and abroad.

Articles by Thomas E. Keane, MD

Bones, Hot Flashes, and ADT Use With Chemotherapy and Timing

These downloadable slides by Dr. Thomas E. Keane, MD are on the topic of the mechanisms of action of ADT treatment for men with prostate cancer. These slides were presented at a satellite symposium presented in conjunction with the AUA Annual Meeting held on Sunday, May 14, 2017 entitled “Navigating the Adverse Effects of ADT: Improving Patient Outcomes. Download...

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New Concepts in Androgen Deprivation Therapy

Dr. Thomas E. Keane presented “New Concepts in Androgen Deprivation Therapy” at the 27th annual International Prostate Cancer Update meeting on Thursday, January 26, 2017.       Keywords: prostate cancer, ADT, agonist,  cardiovascular, chemotherapy, degarelix, docetaxel, enzalutamide How to cite:  Keane, Thomas E. “New Concepts in ADT” January 26, 2017. Accessed Dec 2017. https://grandroundsinurology.com/new-concepts-androgen-deprivation-therapy Transcript New Concepts in Androgen Deprivation Therapy   We’ve all seen this slide for a million years, but it is a brilliant slide, and we have to awknowledge that, thank you, David. That’s your addition. If you look at the far side, however, we see where the future...

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Vitamin D and Prostate Cancer

Dr. Thomas E. Keane presented “Vitamin D and Prostate Cancer” at the 6th Symposium on the Treatment of Prostate Cancer (STOP-6), which was held in Lisbon, Portugal between October 14th and 16th 2016. STOP-6 was accredited for CME by the European Accreditation Council for CME (UEMS-EACCME). The meeting was organized by Bioscript and the Scientific Committee, composed of Professors Laurence Klotz (Chair), Noel Clarke, Karim Fizazi and Bertrand Tombal. Funding to support this educational activity was provided by FERRING Pharmaceuticals. FERRING did not influence meeting content and the views expressed during the meeting represent only those of the faculty.  ...

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Agonists and Antagonists: A Review of What is Known and Recent Data on Disease-Related Outcomes from a Pooled Analysis

Dr. Thomas E. Keane spoke at the 16th Future Directions in Urology Symposium on Monday, August 10, 2015 on “Agonists and Antagonists: A Review of What is Known and Recent Data on Disease-Related Outcomes from a Pooled Analysis.” Presentation   Keywords agonist, antagonist, androgen deprivation therapy (ADT), anti-androgens, degarelix, GnRH receptor How to cite: Keane, Thomas E. “Agonists and Antagonists: A Review of What is Known and Recent Data on Disease-Related Outcomes from a Pooled Analysis” Grand Rounds in Urology. September 18, 2015. Accessed Dec 2017. https://grandroundsinurology.com/agonists-antagonists‎ Transcript Agonists and Antagonists: A Review of What is Known and Recent Data on Disease-Related...

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LHRH Agonists and Antagonists: A Review of What Is Known and Recent Data

Dr. Thomas Keane  spoke at the 25th International Prostate Cancer Update on Friday, January 23, 2015 on “LHRH Agonists and Antagonists: A Review of What Is Known and Recent Data.” Presentation   Keywords: ADT, testosterone-FSH control, cardiovascular disease, LHRH agonists, LHRH Antagonists How to cite: Keane, Thomas. “LHRH Agonists and Antagonists: A Review of What Is Known and Recent Data” Grand Rounds in Urology. April 13, 2015. Accessed Dec 2017. https://grandroundsinurology.com/prostate-cancer-thomas-keane-lhrh-agonists-and-antagonists/. Transcript LHRH Agonists and Antagonists: A Review of What Is Known and Recent Data I was asked to talk about the antagonists. I was asked to give a history, and really I’ve...

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