Gerald L. Andriole, Jr., MD, presented “PSA Screening in 2023” during the 42nd Annual Ralph E. Hopkins Urology Seminar on February 1, 2023, in Jackson Hole, Wyoming.

How to cite: Andriole, Gerald L. PSA Screening in 2023.” February 1, 2023. Accessed Jun 2024. https://grandroundsinurology.com/psa-screening-in-2023/

PSA Screening in 2023 – Summary

Gerald L. Andriole, Jr., MD, former Director of Urology in the National Capital Region at the Brady Urologic Institute at Johns Hopkins University, reviews evidence supporting a more comprehensive family history and biomarkers in screening and treating prostate cancer. Dr. Andriole underscores the power of well-taken family histories, and suggests doctors counsel patients on their hereditary risk of prostate cancer, emphasizing the importance of one diagnosed high-risk family member, to reduce the rate of mortality.

Describing the Germline Mutations in Metastatic PCa, Dr. Andriole recommends all patients with prostate cancer who have certain characteristics be encouraged to speak to their physicians about whether they may need genetic testing for an inherited mutation. When looking in detail at polygenic risk scores (GRS,) knowledge of high GRS decreased the mortality rate.

Dr. Andriole highlights the Prompt Test, the direct-to-consumer, poly-genomic test in the US. In comparison, the UK Biobank data compares prevalence and hazard ratio to show the frequency is higher, some predict cancer aggressiveness. He expects to hear a lot about the prompt test in the future.

Dr. Andriole recommends identifying patients with clinically significant PCa earlier through a lower PSA cutpoint. He suggests using image-guided Micro US or MRI, or a transperineal biopsy to show potentially indicative biomarkers.

About The 42nd Annual Ralph E. Hopkins Urology Seminar:

The Ralph E. Hopkins Urology Seminar is a multi-day meeting focused on training urologists in the latest in assessing, diagnosing, and treating urologic conditions in the clinical setting. Updates are provided on urologic cancers, stone disease, urologic reconstruction, female urology, infertility, sexual function, emerging surgical techniques, and general urology. The 42nd iteration of the meeting took place from February 1st to 4th, 2023, in Jackson Hole, Wyoming.

For further educational activities from this conference, visit our collection page.