Ryan P. Terlecki, MD, presented “The Prostate – Most Diseased Organ in the Male Body” during the 30th Annual International Prostate Cancer Update on January 23rd, 2020 in Beaver Creek, Colorado.

How to cite: Terlecki, Ryan P. The Prostate – Most Diseased Organ in the Male Body” January 23rd, 2020. Accessed Jul 2024. https://grandroundsinurology.com/the-prostate-most-diseased-organ-in-the-male-body​​/

The Prostate – Most Diseased Organ in the Male Body – Summary:

Ryan P. Terlecki, MD, Vice Chair and Associate Professor of Urology, as well as Director of the Men’s Health Clinic at Wake Forest University Baptist Medical Center, reviews data on inflammation and the prostate’s microbiome as well as general prostatic anatomy in order to establish a better understanding of the biological factors which are connected to PCa and BPH development. High rates of prostatic disease (64% of men by the age of 70 have PCa) suggest that many of the causes of PCa stem from the anatomy and microbiome of the prostate. Dr. Terlecki notes that data supports the notion that PCa and BPH prevalence rise with age, are hormone-dependent, and are associated with inflammation. He takes a close look at these factors and the inner workings of the prostate to display how over the course of an individual’s life, decreases in hormone production causes gland function impairment, resulting in overall prostatic inefficiencies which lead to a gradually increasing chance of developing PCa or BPH.

About The 30th Annual International Prostate Cancer Update:

The International Prostate Cancer Update (IPCU), founded in 1990, is a multi-day CME conference focused on prostate cancer treatment updates with expert, international faculty. It is led by expert physicians and is designed for urologists, medical oncologists, radiation oncologists, and other healthcare professionals involved in the diagnosis and treatment of prostate cancer. Dr. Terlecki delivered this educational activity during the 30th iteration of the meeting in January 2020.

For further educational activities from this conference, visit our collection page.


Ryan P. Terlecki, MD, FACS, is a reconstructive urologist for Atrium Health Wake Forest Baptist Medical Center, an academic Level 1 trauma center in Winston-Salem, North Carolina. Dr. Terlecki holds the rank of Professor and the title of Vice Chair of Research for the Department of Urology. In addition, Dr. Terlecki is Director of the Men’s Health Clinic, Director of Medical Student Education, and Fellowship Director for Reconstructive Urology. He holds a joint appointment in the Department of Obstetrics and Gynecology.

Dr. Terlecki earned his medical degree from Wayne State University School of Medicine and completed residency in general surgery and urology at Detroit Medical Center. Following his residency, Dr. Terlecki completed two separate fellowships in reconstructive surgery. He completed a fellowship at the University of Colorado’s Denver School of Medicine and at UT Southwestern Medical Center in Dallas, Texas.

Dr. Terlecki’s publications cover multiple areas of trauma and reconstruction and his research is focused primarily on models of wound healing and regeneration in the lower genitourinary system. Dr. Terlecki’s areas of expertise include urethral stricture disease, male sexual dysfunction, male incontinence, Peyronie’s disease, chronic testicular pain, hypogonadism, and infertility. He is a member of the Society of Genitourinary Reconstructive Surgeons (GURS), a member of the American Urological Association (AUA), and past president of the North Carolina Urological Association (NCUA).