Jesse N. Mills, MD

Jesse N. Mills, MD

University of California Los Angeles

Los Angeles, California

Dr. Jesse N. Mills, MD, is a clinical professor of urology at the David Geffen School of Medicine at the University of California Los Angeles (UCLA). He is division chief of andrology, director of the Men’s Clinic at UCLA, fellowship director of the UCLA male reproductive medicine and surgery program, and director of UCLA Urology Santa Monica. Dr. Mills is internationally recognized as a thought leader in male fertility, hypogonadism, erectile dysfunction, Peyronie's disease, and microsurgery. He has performed thousands of penile implants, vasectomy reversals, varicocelectomy and complex Peyronie's disease surgeries, and Xiaflex injections over the course of his career. Dr. Mills completed his medical degree at the University of Iowa Hospitals and Clinics in 2001, followed by his residency at the University of Colorado Health Science Center in 2007. He then completed his fellowship at Baylor College of Medicine in 2008 and received his medical board certification in urology from the American Board of Urology in 2010. His clinical specialties revolve around men's health and include male hormone management, sexual and ejaculatory dysfunction, male fertility, and Peyronie's disease. He is also the author of the bestselling book A Field Guide to Men's Health.


Talks by Jesse N. Mills, MD

Deciphering Options for Testosterone Replacement Therapy and Managing Withdrawal

Jesse N. Mills, MD, discusses the importance of testosterone replacement therapy and presents an algorithm for determining treatment and managing withdrawal. He begins with an overview of the history of the study of testosterone, from the first recorded effects of castration to the warning against the over-prescription of testosterone therapy issued in 2015 by the FDA.

Dr. Mills discusses the AUA guidelines for testosterone replacement therapy and the lack of on-label options for treatment. He presents options for on-and-off-label testosterone replacement therapy.

Dr. Mills then presents an algorithm for determining the best treatment option for the patient, beginning by addressing male fertility concerns. He addresses questions of lab work, transference, insurance, administration, and other patient and physician concerns.

Dr. Mills concludes with the discontinuation of testosterone replacement therapy and when it is indicated. He discusses the available options for weaning patients off of testosterone, cautioning strongly against abrupt discontinuation.

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Managing the Man with Ejaculatory Dysfunction

Jesse N. Mills, MD, presents management strategies for men presenting with ejaculatory dysfunctions, ranging from premature ejaculation to ejaculodynia. He begins by acknowledging that there is no current FDA-approved treatment specifically for any kind of ejaculatory dysfunction.

Dr. Mills then separates men presenting with ejaculatory dysfunction into distinct categories based on the symptom they are experiencing, and follow-up questions to ask these patients. These five main groups are Premature Ejaculation, Delayed Ejaculation, Anejaculation, Ejaculodynia, and Post-Orgasmic Illness Syndrome.

Throughout the presentation, Dr. Mills discusses each category of dysfunction and available treatment options. He concludes by highlighting the need for further study of post-orgasmic illness syndrome.

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In-office Therapies for Men with Erectile Dysfunction

Jesse N. Mills, MD, discusses the effectiveness of a selection of experimental in-office therapies for erectile dysfunction treatment. Throughout his presentation, Dr. Mills explores the outlook, benefits, and challenges of experimental therapy options currently pushed by external market forces, including:

Low-intensity Shockwave Therapy (LiSWT)
Platelet-Rich Plasma (PRP)
Stem Cell Therapy
Intracavernosal Injection (ICI)
Hyperbaric Oxygen

Dr. Mills concludes by stressing that although these therapy options are still considered experimental, urologists should strive to observe these therapies and hold balanced conversations with patients regarding their efficacy. He encourages urologists to stay optimistic about erectile dysfunction treatment as stewards of male health, suggesting they watch for new data in the world of experimental treatments.

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Off-Label Use of Xiaflex for Peyronie’s Disease

Jesse N. Mills, MD, Associate Clinical Professor and Director of the Men’s Clinic at UCLA, discusses techniques for Xiaflex on and off label, and when and how it can be used to treat Peyronie’s disease. These include alternative injection techniques, plaques involving the penile urethra, use for men on anticoagulation treatments, and non-goniometric deformity.

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